PMID: 8593274Jan 31, 1996Paper

Effects of glucose and its oligomers on the stability of freeze-dried liposomes

Biochimica Et Biophysica Acta
T SuzukiK Miyajima

Abstract

The effects of glucose and its oligomers (maltodextrins) on the stability of sonicated liposomes during freeze-drying were studied by monitoring the retention of the fluorescent dye, Calcein, entrapped in the liposomal inner aqueous phase and by the use of differential scanning calorimetry (DSC). Glucose showed weak cryoprotective effects on dioleoylphosphatidylcholine (DOPC) or egg yolk phosphatidylcholine (eggPC) liposomes, while it had a relatively high cryoprotective effect on dipalmitoylphosphatidylcholine (DPPC) liposomes. Maltose and maltotriose showed high cryoprotective effects on eggPC liposomes, while other maltodextrin, longer oligomers, showed low cryoprotective effects. No saccharide was effective to protect DOPC liposomes. The fluidity and/or packing of lipid membranes had considerable influences on the stability of liposomes during the lyophilization. Maltodextrins showed relatively high cryoprotective effects on DPPC liposomes at low saccharide/lipid molar ratios, although the cryoprotective effects decreased with the increase in the molar ratios. Size measurements suggested that glucose and maltose completely prevented the aggregation and/or fusion of liposomes during lyophilization, and that other maltodextri...Continue Reading

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Citations

Mar 18, 2009·Cellular and Molecular Life Sciences : CMLS·David P LivingstonArnd G Heyer
Feb 18, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·E C van Winden, D J Crommelin
Jan 26, 2016·The Journal of Pharmacy and Pharmacology·Jianying LiDi Zhang
Nov 7, 2009·Journal of Pharmaceutical Sciences·Per WessmanDenny Mahlin
Dec 30, 2009·Journal of Pharmaceutical Sciences·Stepán KoudelkaJaroslav Turánek
Oct 5, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Afzal R MohammedYvonne Perrie
Oct 24, 2009·Journal of Liposome Research·Chengmei LiuWeilin Liu
Jun 24, 2008·Biochimica Et Biophysica Acta·Changfeng Chen, Carl P Tripp
Apr 28, 2007·Biochimica Et Biophysica Acta·Dirk K HinchaArnd G Heyer
Oct 31, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chengjun ChenXing Tang
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Ken-ichi IzutsuShigeo Kojima
Aug 30, 2018·Pharmaceutics·Silvia FranzéFrancesco Cilurzo
Jan 1, 1997·Progress in Biophysics and Molecular Biology·C S Sundari, D Balasubramanian
Mar 30, 2021·International Journal of Pharmaceutics·Lirui JiaYongjun Wang
Apr 18, 2000·Journal of Colloid and Interface Science·A Millqvist-FurebyB Bergenståhl
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·A MemoliF Alhaique
Feb 16, 2002·Cryobiology·A E OliverJ H Crowe
Mar 5, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Brian E OeffingerMargaret A Wheatley

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