Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice

Molecular Medicine Reports
R LennoxPeter R Flatt

Abstract

It has been previously demonstrated that compromise of glucose-dependent insulinotropic polypeptide receptor (GIPR) action and chronic consumption of a high-fat diet can independently impair memory and learning ability, however, the underlying pathology remain to be elucidated. The present study investigated the effects of GIPR knockout (KO), alone and in combination with a high-fat diet, on aspects of cognitive function and hippocampal gene expression in mice. In object recognition tests, normal mice exhibited effective memory, preferring to investigate the novel over the familiar object. However, wild-type (WT) mice fed a high-fat diet and GIPR KO mice fed a standard or high-fat diet demonstrated no such discrimination, suggesting the impairment of memory function. This decline in cognitive function was associated with marked changes in the expression levels of hippocampal genes involved in memory and learning. The chronic consumption of a high-fat diet decreased the hippocampal gene expression levels of mammalian target of rapamycin (mTOR), neurotrophic tyrosine kinase receptor type 2 (NTRK2) and synaptophysin. Notably, the GIPR KO mice fed a high-fat diet exhibited no reduction in the hippocampal expression of synaptophysin...Continue Reading

References

Feb 27, 2001·Neurobiology of Learning and Memory·C E Greenwood, G Winocur
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 20, 2004·Nature Genetics·Lei CaoMatthew J During
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenny NybergPeter S Eriksson
Oct 15, 2005·Neurobiology of Aging·Geert Jan Biessels, Willem Hendrik Gispen
Jul 11, 2006·Peptides·Ke-Hong DingCarlos M Isales
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
Apr 11, 2007·Archives of Neurology·José A LuchsingerRichard Mayeux
May 19, 2007·Journal of Neuroscience Research·Jenny NybergPeter S Eriksson
Sep 30, 2008·Experimental Neurology·Konstanze PlaschkeHugo H Marti
Nov 26, 2008·British Medical Bulletin·Mark W J StrachanJacqueline F Price
Dec 8, 2009·Trends in Neurosciences·Charles A Hoeffer, Eric Klann
Dec 24, 2009·Learning & Memory·Nicola J BroadbentRobert E Clark
Mar 31, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V A GaultC Hölscher
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaday MichánValter D Longo
Nov 26, 2011·European Journal of Pharmacology·Emilie FaivreChristian Hölscher
Jun 6, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W D PorterV A Gault

❮ Previous
Next ❯

Citations

Jun 19, 2018·Expert Opinion on Therapeutic Targets·Mahip K VermaKumar V S Nemmani
Aug 18, 2016·American Journal of Physiology. Endocrinology and Metabolism·Paul B HigginsFranco Folli
Feb 27, 2020·International Journal of Molecular Sciences·Yusaku MoriSho-Ichi Yamagishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.