PMID: 44196Dec 15, 1979

Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans

The Biochemical Journal
S J Ashcroft, M R Christie


The maximal extractable activity of "malic" enzyme (EC in rat islets of Langerhans was similar to that reported for liver. Thus "malic" enzyme may catalyse a near-equilibrium reaction in the cytosol of islets of Langerhans. Measurements of islet content of malate and pyruvate, the metabolite substrate and product of "malic" enzyme, were therefore used to calculate the cytosolic ration of [NADPH]/[NADP+]. This ratio was higher in islets incubated with 20 mM-glucose than in islets incubated with 2 mM-glucose.


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Related Concepts

Malate Dehydrogenase
Pyruvate Measurement
Glucose, (beta-D)-Isomer
Islets of Langerhans

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