Effects of glucose toxicity and islet purity on in vivo magnetic resonance imaging of transplanted pancreatic islets

Transplantation
Natalia V EvgenovA Moore

Abstract

Pancreatic islet transplantation has recently emerged as a powerful clinical modality to restore normoglycemia in diabetic patients. Despite the success of the Edmonton protocol, these patients still experience a significant islet loss immediately after transplantation. Noninvasive magnetic resonance imaging (MRI) allows for longitudinal monitoring of graft loss providing that islets are labeled with a magnetically "visible" contrast agent. To fully interpret the imaging data, it is critical to investigate factors normally present during clinical transplantation and influencing MRI of transplanted islets. Here, we focused on both the effect of hyperglycemia and the effect of contaminating nonendocrine tissue, which is always present in islet preparations, on MRI imaging of islet grafts. Human pancreatic islets labeled with Feridex were transplanted in diabetic and healthy animals. Separate groups of animals were transplanted with Feridex-labeled pure and nonpure (50% islets and 50% nonendocrine tissue) preparations. The fate of the graft in all groups was monitored by in vivo MRI. We found that diabetic animals with transplanted islets showed a significantly higher rate of islet death than their healthy counterparts on in vivo ...Continue Reading

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Citations

Jul 30, 2011·Current Diabetes Reports·Sophie BorotThierry Berney
Oct 18, 2008·Diabetes, Obesity & Metabolism·Z Medarova, A Moore
Oct 21, 2011·Journal of Transplantation·Ping WangAnna Moore
Jul 22, 2009·AJR. American Journal of Roentgenology·Zdravka Medarova, Anna Moore
Apr 11, 2012·International Journal of Molecular Sciences·Macarena PeránJuan A Marchal
Apr 13, 2010·Expert Review of Clinical Immunology·Jamil AzziReza Abdi
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ErikssonT Lundgren
Nov 16, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hoe Suk KimWoo Kyung Moon
May 27, 2009·Nature Reviews. Endocrinology·Willy J MalaisseAbdullah Sener
Jun 24, 2009·Nature Reviews. Endocrinology·Zdravka Medarova, Anna Moore
May 26, 2010·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Sárka Kubinová, Eva Syková
Mar 15, 2018·Journal of Personalized Medicine·Rita Sofia Garcia RibeiroUwe Himmelreich

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