Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Tiago Tomazini GonçalvesFernanda Bm Priviero

Abstract

The aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD). After weaning, male Wistar rats were fed with an HFD plus fructose for 12 weeks and started receiving oral antioxidant supplementation and/or physical training after the fourth week of diet for eight further weeks. Body weight, epididymal and retroperitoneal fat, plasma glucose and lipids, oxidative status and mesenteric artery reactivity were evaluated. Rats fed with HFD presented higher body weight gain and fat accumulation compared to control rats, while GH supplementation did not influence these parameters. Physical training reduced the body weight gain and fat accumulation and modulated the oxidative status by increasing superoxide dismutase activity and total antioxidant capacity and reducing lipid peroxidation. GH alone decreased lipid peroxidation. However, when given to exercised rats, it impaired the response elicited by physical training. HFD caused endothelial dysfunction, and neither GH nor physical exercise prevented it. Potency of sodium nitroprusside w...Continue Reading

Citations

May 27, 2020·Oxidative Medicine and Cellular Longevity·Ivo Vieira de Sousa NetoRita de Cassia Marqueti
Jul 14, 2020·Frontiers in Cell and Developmental Biology·Ivo Vieira de Sousa NetoRita de Cassia Marqueti
Dec 30, 2020·Nutrients·Francisco Javier Martínez-NogueraPedro E Alcaraz

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Methods Mentioned

BETA
MDA
transglycosylation
Assay

Software Mentioned

GraphPad
GraphPad Prism

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