Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level

Journal of Nutritional Science and Vitaminology
Yoshikatsu MiwaMasayoshi Kibata

Abstract

Although hesperidin lowers serum total cholesterol (TC) or triglyceride (TG) in animal models, its effect in humans remains unclear. Using a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), as a hesperidin source, we examined the efficacy on hyperlipidemic subjects. G-Hesperidin was administered to the subjects at 100 or 500 mg/d for 6 wk. The percentage of subjects who had a change in serum cholesterol levels was less than 20%. However, 45-55% of the total subjects showed a reduction in serum TG level. The subjects were classified into normal (TC<230mg/dL, TG<150mg/dL), high-TC (TC>230 mg/dL, TG<150 mg/dL) and high-TG (TG>150 mg/dL) types. While serum cholesterol levels scarcely changed in any phenotype, TG level was significantly reduced by administration in the high-TG type. In this phenotype, serum apolipoprotein (apo) C-II and E levels decreased by the administration, but non-apo B. G-Hesperidin also raised low-density lipoprotein (LDL)-cholesterol/apo B in the high-TG type. These results indicate that G-hesperidin preferentially lowers serum TG in hypertriglyceridemic subjects and that this effect is possibly caused by the facilitation of catabolism of TG-rich lipoproteins and may contribute to the reduc...Continue Reading

Citations

Sep 14, 2006·Journal of Nutritional Science and Vitaminology·Yoshikatsu MiwaMasayoshi Kibata
Mar 12, 2015·Journal of the American College of Nutrition·F HaidariE Shirbeigi
Oct 30, 2016·Critical Reviews in Food Science and Nutrition·Chaoyun Li, Hermann Schluesener
Jun 24, 2006·Bioscience, Biotechnology, and Biochemistry·Mika YamadaMasayoshi Kibata
Nov 12, 2010·The American Journal of Clinical Nutrition·Christine MorandAndrzej Mazur
Jun 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aya UmenoYasukazu Yoshida
Apr 10, 2019·Oxidative Medicine and Cellular Longevity·Ayman M MahmoudOmnia E Hussein
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila R FerrazWaldiceu A Verri
Apr 5, 2017·The Journal of Medical Investigation : JMI·Hitomi KobayashiTohru Sakai
Oct 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Babalwa U JackCarmen Pheiffer

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