PMID: 6163516Nov 1, 1980Paper

Effects of glutamate and aspartate on ataxic gait induced by 3-acetyl pyridine in rats

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
G DeMicheleA Barbeau

Abstract

The main purpose of this study was to examine the effects of intraventricular injections of glutamate and aspartate on the walking gait of rendered ataxic by the administration of 3-acetyl pyridine. Both amino acids significantly improved the walking gait of these animals. The effects of other substances known to have a stimulatory influence on locomotor activity in rats were also investigated. Amphetamine, apomorphine and thyrotropin releasing hormone (TRH) had no effect on the ataxic gait of 3-AP treated animals. Substance P significantly improved the gait of ataxic animals, but to a lesser extent than that seen with glutamate and aspartate.

References

May 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·F B JolicoeurA Barbeau
May 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R HuxtableA Barbeau
Aug 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·N Robinson

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Citations

May 1, 1982·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G De MicheleA Barbeau

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