PMID: 2119440Jul 1, 1990Paper

Effects of glutamine-enriched parenteral nutrition on the exocrine pancreas

JPEN. Journal of Parenteral and Enteral Nutrition
W S HeltonD W Wilmore

Abstract

Total parenteral nutrition (TPN) is associated with intestinal and pancreatic atrophy and pancreatic exocrine insufficiency. Recent investigations have demonstrated that the addition of glutamine to intravenous feedings attenuates TPN-associated intestinal atrophy. However, the effect of glutamine-supplemented intravenous feedings on the pancreas of intact animals is unknown. This study compared the effects of an intravenous infusion of a 2% glutamine-enriched diet (GLN) with an isonitrogenous, isocaloric diet without glutamine (CONT) on the composition and structure of the exocrine pancreas in laboratory rats with and without a 60% small bowel resection. In nonresected, TPN-fed animals, pancreatic weight was significantly increased in the GLN group when compared to CONT (645 +/- 33 g vs 554 +/- 20 g, p less than 0.05). Nonresected GLN animals also had increased pancreatic DNA (3.82 +/- 0.19 mg vs 2.91 +/- 0.49 mg, p less than 0.005) and protein contents (93.0 +/- 5.9 mg vs 76.6 +/- 7.0 mg, p = 0.08) compared to control. Similar significant increases in pancreatic weight, DNA, and protein were observed in intestinally resected animals fed the glutamine diet. When data from CONT and GLN animals were pooled and analyzed together,...Continue Reading

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Jan 16, 2007·Langenbeck's Archives of Surgery·Eduardo E Montalvo-JaveMichael G Sarr
Jun 12, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Megan D BaumlerGuy E Groblewski
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