Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study

The American Journal of the Medical Sciences
T R ZieglerD W Wilmore

Abstract

Glutamine (Gln) is an important nutrient substrate for lymphocytes and macrophages in vitro. This pilot study evaluated effects of Gln supplementation on circulating lymphocytes and lymphocyte subsets after allogeneic bone marrow transplantation (BMT). Adult patients received either parenteral nutrition supplemented by L-Gln (Gln-PN) or standard Gln-free PN after BMT. Leukocyte and total lymphocyte counts were determined during hospitalization, and flow cytometry studies of peripheral mononuclear cells were performed 1 to 2 weeks after hospital discharge. The Gln-PN group demonstrated a higher percentage of blood lymphocytes during hospitalization. At flow cytometry, patients who received Gln-PN had an increased total lymphocyte count (332 +/- 50 versus 590 +/- 71 cells/microL, P = 0.010); greater numbers of total T lymphocytes (54 +/- 19 versus 229 +/- 70 cells/microL, P = 0.030); and higher CD4+ and CD8+ T-lymphocyte counts in peripheral blood compared with controls. Gln-PN may support lymphocyte recovery after BMT.

References

Sep 1, 1990·Lancet·M Parry-BillingsE A Newsholme
Jun 1, 1985·The Journal of Experimental Medicine·K A AultB R Smith
Aug 1, 1985·Journal of Cellular Physiology·J Crawford, H J Cohen
May 29, 1993·Lancet·R R van der HulstP B Soeters
Feb 1, 1996·The Journal of Laboratory and Clinical Medicine·K M Skubitz, P M Anderson

❮ Previous
Next ❯

Citations

Dec 3, 1999·Amino Acids·P C Calder, P Yaqoob
Mar 19, 2003·Current Infectious Disease Reports·Benedito A. Carneiro-FilhoRichard L. Guerrant
Dec 17, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Jun 28, 2000·Nutrition·T R Ziegler, N M Daignault
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
Nov 20, 2003·Nutrition·Rosângela Passos de Jesus MazzaDan Linetzky Waitzberg
Feb 16, 2000·Nutrition·P C Calder
Feb 16, 2000·Nutrition·S F Abcouwer
Jun 6, 2000·Critical Reviews in Oncology/hematology·G Nitenberg, B Raynard
Nov 21, 2007·The British Journal of Nutrition·Philip C Calder
Feb 22, 2007·European Journal of Clinical Nutrition·H SahinE Ok
Jul 4, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Concepción F EstívarizThomas R Ziegler
May 19, 2000·The Proceedings of the Nutrition Society·L O'Flaherty, D J Bouchier-Hayes
Feb 9, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Menghua LuoThomas R Ziegler
Jan 1, 2009·The Journal of Medical Investigation : JMI·Raisa KhropychevaVasiliy Zolotarev
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·D W WilmoreT R Ziegler
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·T R ZieglerR G Martindale
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·R D Griffiths
Apr 4, 2007·The British Journal of Nutrition·Peng LiGuoyao Wu
Oct 7, 2006·Current Opinion in Gastroenterology·P Kitchen, A Forbes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.