Effects of glyburide on ischemia-induced changes in extracellular potassium and local myocardial activation: a potential new approach to the management of ischemia-induced malignant ventricular arrhythmias

American Heart Journal
S S BekheitN el-Sherif

Abstract

The increase in extracellular potassium [K+]o levels during the early phase of myocardial ischemia may result in part from activation of adenosine triphosphate-sensitive K+ channels. Glyburide, a second-generation hypoglycemic sulfonylurea, is a potent blocker of these channels. We studied the effects of glyburide on [K+]o and on intramyocardial conduction delay during a 10-minute occlusion of the left anterior descending artery in the dog. K(+)-sensitive electrodes and bipolar plunge electrodes were introduced to record, respectively, [K+]o and local electrograms from close sites in midmyocardial regions in normal, border, and ischemic zones. Recordings were obtained before (control ischemia [CI]) and 20 minutes after intravenous administration of 0.15 mg/kg of glyburide (glyburide plus ischemia [G + I]). During G + I the extent of the increase in [K+]o was less compared to that during CI, and the difference was statistically significant during the first 7 minutes of ischemia in the ischemic zone and during the first 4 minutes of ischemia in the border zone. On the other hand, the degree of local intramyocardial conduction delay was significantly reduced during G + I compared to CI during the entire 10 minutes of ischemia in b...Continue Reading

References

Jul 15, 1987·Biochemical and Biophysical Research Communications·H Schmid-AntomarchiM Lazdunski
Feb 1, 1988·Journal of the American College of Cardiology·D DavidL S Dreifus
Aug 1, 1973·Journal of Molecular and Cellular Cardiology·P P Mathur, R B Case
Jan 1, 1971·Cardiology·R B Case
Jun 1, 1966·American Heart Journal·A S Harris
May 1, 1984·Journal of Molecular and Cellular Cardiology·A G Kléber
Jul 1, 1981·Journal of Molecular and Cellular Cardiology·J Weiss, K I Shine
Jul 1, 1981·Basic Research in Cardiology·R FriedrichR Bissig
Jan 1, 1962·The Journal of Clinical Investigation·R ANDRESK L ZIERLER
Aug 11, 1941·The Journal of Physiology·P J Boyle, E J Conway

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Citations

Jan 10, 2002·European Journal of Pharmacology·Ryuichi SatoTaku Nagao
Mar 12, 2010·The New England Journal of Medicine·Barry J Maron, N A Mark Estes
Sep 19, 2003·Journal of the American College of Cardiology·Jose F HuizarHarton S Smith
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·J K SmallwoodM I Steinberg
Apr 1, 1997·Pacing and Clinical Electrophysiology : PACE·F A Ehlert, J J Goldberger
Dec 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dang Van CuongJin Han
Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
Aug 1, 1993·Cardiovascular Drugs and Therapy·J N Weiss, N Venkatesh
Mar 1, 1995·Cardiovascular Drugs and Therapy·W HaverkampG Breithardt
Aug 1, 1993·Cardiovascular Drugs and Therapy·A A Wilde
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Rakesh C Kukreja
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S OkuboR C Kukreja
Jul 17, 1999·The American Journal of Physiology·N L BernardoR C Kukreja
Jul 1, 1996·Diabetes Research and Clinical Practice·M Z Koltai
Jul 1, 1996·Diabetes Research and Clinical Practice·A Végh, J G Papp
Oct 1, 1993·Journal of the American College of Cardiology·S BekheitN el-Sherif

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