PMID: 34413Dec 1, 1978

Effects of glycopyrrolate and cimetidine on gastric volume and acidity in patients awaiting surgery

British Journal of Anaesthesia
P J KeatingD W Watson

Abstract

Glycopyrrolate or cimetidine was administered before operation to patients undergoing elective surgery. After the induction of anaesthesia, the stomach contents were retrieved and the volume and pH measured. Neither drug diminished the volume of gastric contents compared with control. Glycopyrrolate produced little diminution in hydrogen ion concentration. Cimetidine caused a marked increase in pH with a mean [h+] 3.2 x 10(-3) g litre-1 compared with 1.4 x 10(-2) g litre-1 in the controls and 1.1 x 10(-2) g litre-1 in the glycopyrrolate group. Seventy-seven per cent of the patients receiving cimetidine had a pH greater than 2.5.

Citations

Sep 1, 1982·Klinische Wochenschrift·G FeifelH Eissner
Jul 1, 1979·Canadian Anaesthetists' Society Journal·D J Wright, A Pandya
May 1, 1983·Canadian Anaesthetists' Society Journal·J G Williams
Nov 1, 1983·Canadian Anaesthetists' Society Journal·A S OkashaA Bali
Jan 1, 1981·General Pharmacology·R K Mirakhur, J W Dundee
Sep 17, 1981·The New England Journal of Medicine
May 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M E Kinni, M M Stout
Dec 1, 1983·Anaesthesia·R K Mirakhur, J W Dundee
Feb 1, 1981·Anaesthesia·W McCaugheyJ W Dundee
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·F Kongsrud, S Sponheim
Jan 1, 1980·Acta Anaesthesiologica Scandinavica·P KirkegaardP Kirkegaard
Nov 1, 1980·Anaesthesia and Intensive Care·P J Barnes, J H Havill
May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky
May 1, 1983·Anaesthesia and Intensive Care·J G Brock-UtneJ Gjessing

Related Concepts

Tagamet
Glycopyrrolate
Guanidines
Hydrogen-Ion Concentration
Preoperative Procedure
Pyrrolidines
Stomach
Operative Surgical Procedures

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