PMID: 375245Jan 1, 1979Paper

Effects of goldthioglucose lesions on central catecholamine levels in the mouse

Pharmacology, Biochemistry, and Behavior
J F LordenM Callahan

Abstract

Male and female C57 B1/6J mice were injected with goldthioglucose (GTG) to induce an obesity syndrome. Significant increases in body weight were inversely correlated with pituitary dopamine (DA) levels. Significant reductions in hypothalamic norepinephrine (NE) and DA were also noted; however, these reductions did not appear to be related to body weight gain. The GTG injections did not produce any significant alterations in telencephalic NE or DA. The damage to catecholamine neurons is discussed in relation to the endocrine abnormalities of the GTG mouse and some current hypotheses on the control of food intake.

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Citations

Mar 5, 1986·Brain Research·T L Powley, J C Prechtl
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·E KishiY Maruyama
Oct 7, 2011·Journal of Lesbian Studies·Wan-Chuan Kao
Jul 1, 1997·The American Journal of Physiology·R DawsonB Eppler

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