PMID: 6983555Nov 1, 1982Paper

Effects of gonadal steroid hormones on the hypothalamo-pituitary-liver axis in the control of sex differences in hepatic steroid metabolism in the rat

The Journal of Endocrinology
A Mode, G Norstedt

Abstract

The site of action of gonadal hormones in the regulation of hepatic steroid metabolism was investigated by measuring the effects of (i) implantation of estradiol into the pituitary gland or anterior hypothalamus of males and (ii) subcutaneous injection of a synthetic androgen in differentiated male and female rats. The hepatic responses measured in vitro were 5 alpha-reduction, and 6 beta- and 16 alpha-hydroxylation of androstenedione. After intrapituitary or intrahypothalamic implantation of oestradiol, 5 alpha-reductase activity increased and 6 beta- and 16 alpha-hydroxylase activity decreased in males relative to the enzyme activities of cholesterol-implanted animals, indicating a feminizing effect of the oestrogen. This effect could not be accomplished by subcutaneous injection of the same oestrogen preparation. Deafferentation had no effect on hepatic steroid metabolism in females, but caused a feminization in males. In addition, subcutaneous treatment of intact females with the synthetic androgen caused masculinization of hepatic steroid metabolism, but was without effect in differentiated animals. Treatment with synthetic androgens had no effect on the hepatic steroid metabolism in differentiated male animals. Subcutaneo...Continue Reading

Citations

Sep 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·O V SmirnovaV B Rozen
Jan 1, 1985·Steroids·E H YuenB J Wilson
Feb 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A López-GuerraB N Díaz-Chico
Apr 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Susanne LöfgrenMagnus Ingelman-Sundberg
Jun 15, 2005·BMC Physiology·Nina StåhlbergAmilcar Flores-Morales
Jan 27, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J TakahashiS Fujita
Sep 7, 2012·PloS One·Sandeep KadekarUlla Stenius

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