Abstract
The site of action of gonadal hormones in the regulation of hepatic steroid metabolism was investigated by measuring the effects of (i) implantation of estradiol into the pituitary gland or anterior hypothalamus of males and (ii) subcutaneous injection of a synthetic androgen in differentiated male and female rats. The hepatic responses measured in vitro were 5 alpha-reduction, and 6 beta- and 16 alpha-hydroxylation of androstenedione. After intrapituitary or intrahypothalamic implantation of oestradiol, 5 alpha-reductase activity increased and 6 beta- and 16 alpha-hydroxylase activity decreased in males relative to the enzyme activities of cholesterol-implanted animals, indicating a feminizing effect of the oestrogen. This effect could not be accomplished by subcutaneous injection of the same oestrogen preparation. Deafferentation had no effect on hepatic steroid metabolism in females, but caused a feminization in males. In addition, subcutaneous treatment of intact females with the synthetic androgen caused masculinization of hepatic steroid metabolism, but was without effect in differentiated animals. Treatment with synthetic androgens had no effect on the hepatic steroid metabolism in differentiated male animals. Subcutaneo...Continue Reading
Citations
Sep 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·O V SmirnovaV B Rozen
Nov 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·T G VishniakovaV B Rozen
Feb 4, 1992·Biochemical Pharmacology·M J RonisT M Badger
Oct 1, 1985·Journal of Steroid Biochemistry·O V SmirnovaV B Rozen
Feb 1, 1989·Journal of Steroid Biochemistry·B von Schoultz, K Carlström
Jan 1, 1985·Steroids·E H YuenB J Wilson
May 1, 1985·Molecular and Cellular Endocrinology·B HusmanJ A Gustafsson
Feb 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A López-GuerraB N Díaz-Chico
Apr 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Susanne LöfgrenMagnus Ingelman-Sundberg
Jun 15, 2005·BMC Physiology·Nina StåhlbergAmilcar Flores-Morales
Jan 27, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J TakahashiS Fujita
Apr 1, 1984·Cell·G Norstedt, R Palmiter
Feb 9, 1996·Biochemical Pharmacology·T K ChangG D Bellward
Jun 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·R F WitkampA S Van Miert
Jul 28, 1999·Biochemical Pharmacology·M Murray, A M Butler
Sep 7, 2012·PloS One·Sandeep KadekarUlla Stenius
Mar 25, 2014·PloS One·Hong-Bo GuanTingting Gong
Jan 29, 2000·Clinical Endocrinology·A A ToogoodJ P Monson
Oct 24, 2001·Biology of Reproduction·O PutzG S Prins
Sep 10, 2010·The Journal of Clinical Endocrinology and Metabolism·Alexandra J SinclairJeremy W Tomlinson
Aug 31, 2000·Endocrinology·H K Choi, D J Waxman
Jan 1, 1987·Journal of Steroid Biochemistry·E R Lax