Effects of graded mechanical compression of rabbit sciatic nerve on nerve blood flow and electrophysiological properties

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Takafumi YayamaHisatoshi Baba

Abstract

Entrapment neuropathy is a frequent clinical problem that can be caused by, among other factors, mechanical compression; however, exactly how a compressive force affects the peripheral nerves remains poorly understood. In this study, using a rabbit model of sciatic nerve injury (n=12), we evaluated the time-course of changes in intraneural blood flow, compound nerve action potentials, and functioning of the blood-nerve barrier during graded mechanical compression. Nerve injury was applied using a compressor equipped with a custom-made pressure transducer. Cessation of intraneural blood flow was noted at a mean compressive force of 0.457+/-0.022 N (+/-SEM), and the compound action potential became zero at 0.486+/-0.031 N. Marked extravasation of Evans blue albumin was noted after 20 min of intraneural ischemia. The functional changes induced by compression are likely due to intraneural edema, which could subsequently result in impairment of nerve function. These changes may be critical factors in the development of symptoms associated with nerve compression.

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Citations

Oct 28, 2010·Head & Face Medicine·Sareh Said YektaRalf Smeets
Aug 2, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sareh Said-YektaFriedrich Lampert
Jul 9, 2016·Hand : Official Journal of the American Association for Hand Surgery·Yuichi YoshiiTomoo Ishii
Oct 25, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Tsuyoshi TajikaKenji Takagishi
Jul 11, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·G ShumA Clarke
Feb 2, 2017·European Journal of Anaesthesiology·Jean-Pierre Estebe, Arthur Atchabahian
Mar 18, 2016·The Journal of Bone and Joint Surgery. American Volume·Mary Claire ManskeSandra E Klein
May 4, 2021·OTA International : the Open Access Journal of Orthopaedic Trauma·Sadaki MitsuzawaShuichi Matsuda

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