Effects of green tea extracts on the pharmacokinetics of quetiapine in rats

Evidence-based Complementary and Alternative Medicine : ECAM
Essam EzzeldinMuzaffar Iqbal

Abstract

Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats. Male Wistar albino rats received GTE (175 mg/kg) or saline (control) by oral gavage for 7 days before a single intragastric administration of 25 mg/kg quetiapine. Plasma concentrations of quetiapine were measured up to 12 h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy. Pretreatment with GTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and 35%, respectively, compared to quetiapine alone. However, GTE did not produce significant change in elimination half-life and oral clearance of quetiapine. This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.

References

Feb 24, 2001·Journal of Clinical Psychopharmacology·Y W WongP T Thyrum
Aug 21, 2001·Clinical Pharmacokinetics·C L DeVane, C B Nemeroff
Feb 21, 2002·Biochimica Et Biophysica Acta·Julie JodoinRichard Beliveau
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Masataka NishikawaMitsukazu Kitada
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·E H JangJ H Kang
Jan 5, 2006·British Journal of Clinical Pharmacology·Scott W GrimmStots B Reele
Oct 20, 2006·The Journal of Nutritional Biochemistry·Suchitra KatiyarSantosh K Katiyar
Jul 28, 2007·Life Sciences·Naghma Khan, Hasan Mukhtar
May 26, 2009·Preventive Medicine·Yuri Clement
May 28, 2009·Nature Reviews. Cancer·Chung S YangSonia C Picinich
Sep 16, 2009·The British Journal of Nutrition·Rosalind J MooreAnne M Minihane
Dec 4, 2009·Amino Acids·Esther MelgarejoMiguel Angel Medina
Dec 5, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J J JohnsonH Mukhtar
Apr 20, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cristiano Colalto
Sep 4, 2010·Journal of Clinical Psychopharmacology·Eduard VietaBjörn Paulsson
Dec 17, 2010·Expert Review of Neurotherapeutics·A Carlo AltamuraBernardo Dell'Osso
Feb 1, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Megan RothBruno Hagenbuch
Mar 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jinping QiaoWeidong Lu
Aug 17, 2011·Pharmacogenomics·Tim MoonsGeert Dom
Nov 24, 2011·International Clinical Psychopharmacology·Alberto ChiesaAlessandro Serretti
Jun 13, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gry Vibeke BakkenMonica Hermann
May 24, 2013·Drug Metabolism and Pharmacokinetics·Shingen MisakaShizuo Yamada
Aug 8, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S MisakaJ Kimura

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Citations

Nov 3, 2016·Chemical & Pharmaceutical Bulletin·Dong-Wook KimKyung-Tae Lee
Jun 4, 2021·Clinical and Translational Science·Lin XuRodney Rouse

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