Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters.

Journal of Anatomy
Petro JulkunenH J Helminen

Abstract

Articular cartilage composition and structure are maintained and remodeled by chondrocytes under the influence of loading. Exercise-induced changes in the composition, structure, mechanical properties and tissue integrity of growing and aging hamster articular cartilage were investigated. Articular cartilage samples (n = 191) were harvested from the proximal tibiae of hamsters aged 1, 3, 6, 12 and 15 months. The hamsters were divided into runners and controls. The runners had free access to a running wheel between 1 and 3 months (runner groups 3-, 12- and 15-month-old hamsters) or 1 and 6 months (runner group 6-month-old hamsters) of age. Control animals were subjected to a sedentary lifestyle. Mechanical indentation tests and depth-wise compositional and structural analyses were performed for the cartilage samples. Furthermore, the integrity of articular cartilage was assessed using histological osteoarthritis grading. Exercise affected the collagen network organization after a 5-month exercise period, especially in the middle and deep zones. However, no effect on the mechanical properties was detected after exercise. Before the age of 12 months, the runners showed less osteoarthritis than the controls, whereas at 15 months of...Continue Reading

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Citations

Jun 1, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Pamela HansenStuart E Willick
Apr 18, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeffrey BeckettZijun Zhang
May 19, 2012·Osteoarthritis and Cartilage·M A McNultyC S Carlson
Sep 15, 2016·Arthritis Research & Therapy·Benny AntonyChanghai Ding
Feb 1, 2018·Journal of Orthopaedic Surgery and Research·Shilei WangQian Chen
Apr 30, 2019·Scandinavian Journal of Medicine & Science in Sports·Marija MazorHechmi Toumi
Oct 28, 2011·The Physician and Sportsmedicine·Graeme JonesDawn Dore
Oct 5, 2018·JBMR Plus·Parisa R MoshtaghHarrie Weinans

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