Effects of growth factors and receptor blockade on gastrointestinal cancer

Gut
R J PlayfordS Ghosh

Abstract

The advent of recombinant peptide technology offers the potential to use one or several peptides to treat a variety of gastrointestinal conditions. However, although cell culture and animal models have shown proof of concept, we are still at a relatively early stage in translating their use to standard clinical practice. Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established.

References

Jul 6, 1991·Lancet·P B SullivanN A Wright
Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jul 1, 1997·Clinical Endocrinology·P J JenkinsM Besser
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·A Wells
Aug 24, 1999·Pharmacology & Therapeutics·J R Woodburn
Sep 6, 2000·Nature Medicine·C J TorranceC M Discafani
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Reade B RobertsDavid W Threadgill
Aug 7, 2002·The American Journal of Pathology·Jorge BerlangaRaymond J Playford
Jan 10, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara D AbbottJudith E Schmid
Jun 7, 2003·Endocrine-related Cancer·G EmonsC Verschraegen
Jul 25, 2003·The New England Journal of Medicine·Atul SinhaRaymond J Playford
Feb 3, 2004·The Oncologist·Román Pérez-Soler
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzRobert J Mayer

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Citations

Oct 28, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Marco RomanoRaffaele Zarrilli
Jun 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Paul A KitchenJulian R F Walters

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