PMID: 8473829Mar 1, 1993Paper

Effects of growth hormone and thyroxine on kidney insulin-like growth factor-I and renal growth in hypophysectomized rats

The Journal of Endocrinology
S M MarshallH Orskov

Abstract

The effects of treatment for 11 days with human growth hormone (hGH; 140 micrograms/day), thyroxine (T4; micrograms/day) and hGH+T4 on renal growth and content of insulin-like growth factor-I (IGF-I) in hypophysectomized rats have been compared with saline-treated hypophysectomized animals and intact control animals. Right kidney weight and kidney weight/body weight ratio remained low in the saline-treated group (313 +/- 9 mg vs 694 +/- 28 mg in controls on day 11, P < 0.001 and 3.4 +/- 0.12 x 10(-3) vs 4.2 +/- 0.10 x 10(-3), P < 0.005 respectively). In T4- and hGH-treated animals, kidney weight gain was similar (to 420 +/- 14 and 450 +/- 22 mg on day 11 respectively, P > 0.05), whilst the increase was greater in the group given hGH+T4 (to 572 +/- 34 mg, P < 0.001 compared with hGH- and T4-treated groups). The kidney weight/body weight ratio became normal in the T4- and hGH+T4-treated animals but remained low in the hGH-treated group. The renal content of IGF-I was low in the saline-treated animals throughout the study (92 +/- 10 ng/g on day 11 vs 219 +/- 8 ng/g in control animals, P < 0.001), but increased to a maximum of 88% above baseline on day 1 in the group given T4.(ABSTRACT TRUNCATED AT 250 WORDS)

Citations

Mar 30, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mogher KhamaisiAllan Flyvbjerg
Jun 8, 2006·The Journal of Veterinary Medical Science·Ho Jae Han, Soo Hyun Park
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Rakesh Amin, David B Dunger
Sep 1, 1993·Journal of Endocrinological Investigation·A CostaM Ariano

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