PMID: 16628277Apr 22, 2006Paper

Effects of growth hormone on anthropometric and metabolic parameters in android obesity

Arquivos brasileiros de endocrinologia e metabologia
Alfredo HalpernAna Paula A C Costa

Abstract

The aim of the study was to evaluate the effect of GH on body weight, body composition and cardiovascular risk factors in android obese men. Forty non-diabetic subjects aged 20 to 50 years-old with android obesity (WHR > 1) were divided in two groups, on a prospective randomized double-blind basis to receive treatment with GH (0.050 U/kg/day) or placebo for three months. Bioimpedance analysis, DEXA, indirect calorimetry and cardiovascular risk factors were done at the beginning and at the end of the study. Anthropometric measurements were evaluated monthly. Body weight was reduced (3.5 +/- 2.9 kg), as well as BMI (1.2 +/- 1.0 kg/m2), WHR (0.04 +/- 0.01) and fat mass (2.4 +/- 1.0 kg), total cholesterol (4.0 +/- 3.3 mg/dL) and LDL-cholesterol (5.7 +/- 2.7 mg/dL) in GH-treated patients. Percentual changes were statistically different from placebo. Benefits and risks of long-term GH use in obese patients are still largely unknown.

References

Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisG Lizarralde
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·D K SnyderL E Underwood
May 1, 1987·Endocrine Reviews·M B Davidson
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·D K SnyderL E Underwood
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsL E Underwood
Oct 1, 1995·Metabolism: Clinical and Experimental·N MøllerH Orskov
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·M H RasmussenN E Skakkebae
Feb 1, 1995·The American Journal of Medicine·D K SnyderD R Clemmons
Apr 1, 1993·The American Journal of Clinical Nutrition·R RossL Avruch
Oct 2, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M TagliaferriF Cavagnini
Aug 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J SvenssonG Johannsson
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S Y NamK B Huh
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·T MünzerM R Blackman
Mar 1, 1959·The Journal of Clinical Investigation·M S RABEN, C H HOLLENBERG

❮ Previous
Next ❯

Citations

Jul 3, 2013·Sports Medicine·Gwendolyn A ThomasJeff S Volek
Oct 23, 2008·The Journal of Clinical Endocrinology and Metabolism·Kavya C Mekala, Nicholas A Tritos
Apr 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Roberta A LordeloAlfredo Halpern
Nov 30, 2016·The Cochrane Database of Systematic Reviews·Emma MeadLouisa J Ells

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.