Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study.

Journal of Bone and Mineral Metabolism
Lysette IglesiasJohn F Aloia

Abstract

Growth hormone (GH) deficiency causes decreased bone mineral density and osteoporosis, predisposing to fractures. We investigated the mechanism of action of GH on bone modeling and remodeling in hypophysectomized (HX) female rats. Thirty female Sprague-Dawley rats at age 2 months were divided into three groups with 10 rats each: control (CON) group, HX group, and HX + GH (3 mg/kg daily s.c.) group, for a 4-week study. Hypophysectomy resulted in cessation of bone growth and decrease in cancellous bone mass. Periosteal bone formation decreased and bone turnover rate of endocortical and trabecular surfaces increased as compared to the CON group. GH administration for 4 weeks restored weight gain and bone growth and mitigated decrease in bone density after hypophysectomy. However, trabecular bone mass in the proximal tibial metaphysis remained lower in group HX + GH than in group CON. Dynamic histomorphometric analysis showed that bone modeling of periosteal bone formation and growth plate elongation was significantly higher in group HX + GH than in group HX. New bone formed beneath the growth plate was predominately woven bone in group CON and group HX + GH. Bone remodeling and modeling-remodeling mixed modes in the endocortical a...Continue Reading

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Dec 1, 1994·The American Journal of Clinical Nutrition·F Bronner
Jul 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M C Slootweg
Jul 1, 1996·European Journal of Clinical Investigation·E F EriksenB Langdahl
Aug 1, 1997·The American Journal of Physiology·L J MacVinishA W Cuthbert
Mar 12, 1998·Endocrine Reviews·C OhlssonM C Slootweg
Jan 14, 1999·The American Journal of Physiology·J K YehJ F Aloia
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G OrtoftH Oxlund
Jan 13, 2000·Biochemical and Biophysical Research Communications·K SjögrenC Ohlsson
Oct 10, 2002·Hormone Research·J P MonsonM O Savage
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bom-Taeck KimEgo Seeman
Dec 13, 2003·Hormone Research·Marie Bex, Roger Bouillon
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nathalie BravenboerPaul Lips
Nov 10, 2005·The Journal of Clinical Endocrinology and Metabolism·Robert D MurrayStephen M Shalet
May 2, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Jerzy KosowiczJerzy Sowinski
Mar 28, 2009·European Journal of Endocrinology·G S ConwayUNKNOWN 1369 GHD to GHDA Transition Study Group

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Citations

Aug 4, 2016·Journal of Orthopaedic Surgery and Research·Xiaowen XuYan Zhang
Mar 9, 2017·Anais Da Academia Brasileira De Ciências·José A CamassaIsabel R Dias
Jan 26, 2018·Annals of Clinical Biochemistry·J S Kenkre, Jhd Bassett
Feb 13, 2015·The Open Dentistry Journal·George Litsas
Jun 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jungbin SongHocheol Kim
Feb 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gareth RyanAaron Nauth
May 18, 2021·Journal of Clinical Epidemiology·Mark J BollandAndrew Grey

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