Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model.

Carcinogenesis
I P HällströmA Blanck

Abstract

The expression of the oncogenes c-myc and c-fos was studied in Wistar rats treated according to the resistant hepatocyte model. During early phases of promotion, i.e. the first 4 days after partial hepatectomy (PH) when the growth hormone (GH)-dependent sex difference in outgrowth of preneoplastic foci becomes manifest, c-myc and c-fos expression were compared in livers from males, females and GH-treated males. The expression of c-fos was almost doubled in males when compared to females 1 day after PH, a difference that gradually declined during the following days. In males receiving growth hormone in osmotic minipumps from 1 week after initiation the expression was at about the same level as that in females, c-myc expression was enhanced in males from the first day after PH and remained elevated, with a maximal 2.5-fold increase at day 2, while the expression in females and GH-treated males was practically unchanged. The increased c-myc expression in males and the effect of GH was still apparent 28 days after PH. Nuclear transcription assay showed a 2- to 3-fold higher transcription of the c-myc gene in untreated when compared with GH-treated males at the third day after PH. In conclusion, continuous GH infusion was shown to m...Continue Reading

Citations

Feb 14, 2012·Endocrine Pathology·Robert FormosaJosanne Vassallo
Jan 1, 1996·Pharmacology & Therapeutics·D A Weigent
Apr 1, 1994·Molecular and Cellular Endocrinology·A C Herington
Aug 29, 1998·Obstetrics and Gynecology·I L WihmanM Faxén
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·L C Eriksson, G N Andersson
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I P HallstromA Blanck
Jun 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H S JenkeD Oesterle
Jun 1, 1994·Human & Experimental Toxicology·C MacDonaldH Grant
May 1, 1994·Trends in Endocrinology and Metabolism : TEM·P Roupas, A C Herington

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