Effects of growth hormone treatment on the regeneration of rat sciatic nerve

Brain Research
M KanjeG Lundborg

Abstract

The effect of human growth hormone (hGH) on regeneration of neuronal tissue have been studied in rats. A crush lesion was made on the sciatic nerve at the thigh level in intact or hypophysectomized rats. The hGH was administered systemically via subcutaneously implanted miniosmotic pumps. Regeneration was evaluated by the 'pinch-test' after 3, 4 and 6 days. Regeneration was significantly (P less than 0.05) impaired in hypophysectomized rats, but restored to normal after treatment with hGH (200 mIU/day). In intact rats treatment with 400 mIU/day hGH significantly (P less than 0.05) stimulated regeneration, whereas no effect was observed at 200 mIU/day. Immunoreactive insulin-like growth factor 1 (IGF-1) decreased in hypophysectomized rats, but rose again after hGH treatment. However, no consistent correlation between circulating IGF-1 and the rate of regeneration was found. Our results show that hGH can increase the rate of regeneration in peripheral nerves after injury. This can be due either to direct effects of hGH or to indirect effects via locally produced growth factors (e.g. somatomedins).

References

Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
Sep 1, 1985·Brain Research Bulletin·P M EdwardsW H Gispen
Jan 1, 1985·Psychoneuroendocrinology·C Saint-ComeF L Strand
Apr 1, 1986·Acta Physiologica Scandinavica·H A HanssonG Lundborg
Oct 1, 1986·Experimental Neurology·N DanielsenG Lundborg
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J D'ErcoleL E Underwood
Nov 14, 1983·Brain Research·M J Politis, P S Spencer
Apr 1, 1982·Experimental Neurology·A T Yachnis, A L Mescher

❮ Previous
Next ❯

Citations

Jan 1, 1995·Cancer Chemotherapy and Pharmacology·G S Ruigt, M H den Brok
Aug 20, 1993·Brain Research. Developmental Brain Research·P E LobieM J Waters
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jan 6, 2000·Progress in Neurobiology·K OjikaN Matsukawa
Feb 13, 2001·Brain Research Bulletin·P B Farel, D L McIlwain
Oct 1, 1994·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·D T LincolnM J Waters
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·W HasanP M Bouloux
May 1, 1991·British Journal of Pharmacology·C E Van der ZeeW H Gispen
Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·A SkottnerL Fryklund
Mar 24, 1999·Pediatric Research·K GustafsonJ Isgaard
Aug 23, 2008·Endocrinology·Kelli A SullivanEva L Feldman
May 19, 2016·Expert Opinion on Therapeutic Targets·Sami H TuffahaGerald Brandacher
Jan 1, 1992·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·L B Dahlin
Nov 18, 2017·International Journal of Molecular Sciences·Vittorio Emanuele BianchiLaura Rizzi
Mar 24, 2018·Neuroreport·Jennis GabrielpillaiMarc Diensthuber
Nov 4, 2000·The Journal of Urology·A J BeckerU Jonas
Jan 19, 2008·Proteomics·Marie-Laure BaudetSteve Harvey
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Benjamin R SlavinSami H Tuffaha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Endocrinology, Diabetes, and Obesity
Omar Ali, David Wyatt
Handbook of Experimental Pharmacology
Martin Bidlingmaier, Christian J Strasburger
© 2021 Meta ULC. All rights reserved