PMID: 1202994Nov 6, 1975

Effects of guanethidine on paraganglionic cells in the superior cervical ganglion of the rat

Anatomy and Embryology
C Heym, D Grube


Paraganglionic cells in the rat superior cervical ganglion were investigated by fluorescence and electron microscopy following treatment with guanethidine for 5-30 days. Control animals received saline and guanidine. Fluorescence cytophotometric measurements revealed a general decrease in the catecholamine content of paraganglionic cells in guanethidine-treated animals. However a few cell clusters showed focal increases. Similarly by electron microscopy there was a general decrease of cell clusters showing increases. -- guanethidine -- as well as guanidine--treated animals showed non-specific cytological alterations such as mitochondrial swelling and increase of cytoplasmic glycogen. However no changes of catecholamine contents and of dense core vesicles were noted in control animals. These results confirm the conception that in rat paraganglionic cells the dense core vesicles are the main storage site of catecholamines. The marked difference in the response of some cell culsters to the experimental treatment can be considered as evidence of functional heterogeneity of this cell population in the rat superior cervical ganglion.


Nov 23, 1973·Brain Research·A Dahlström
Dec 1, 1968·Journal of Ultrastructure Research·G SiegristC Rouiller
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Hervonen, L Kanerva
Sep 1, 1971·British Journal of Pharmacology·G BurnstockM Wright
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P U Angeletti, R Levi-Montalcini
Apr 1, 1968·European Journal of Pharmacology·T Malmfors, C Sachs
Sep 1, 1969·Brain Research·T H Williams, S L Palay
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT

Related Concepts

Guanethidine Sulfate (2: 1), 14C-Labeled
Mitochondrial Swelling
Paraganglia Structure
Sodium Chloride, (24)NaCl
Chromaffin System
Cytoplasmic Granules
Autonomic Ganglion

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