Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A systematic review.

Psychiatry Research
Jiaxin YangYamin Li

Abstract

Many studies have identified some abnormalities in gastrointestinal (GI) physiology (e.g., increased intestinal permeability, overall microbiota alterations, and gut infection) in children with autism spectrum disorder (ASD). Furthermore, changes in the intestinal flora may be related to GI and ASD symptom severity. Thus, we decided to systematically review the effects of gut microbial-based interventions on gut microbiota, behavioral symptoms, and GI symptoms in children with ASD. We reviewed current evidence from the Cochrane Library, EBSCO PsycARTICLES, PubMed, Web of Science, and Scope databases up to July 12, 2020. Experimental studies that used gut microbial-based treatments among children with ASD were included. Independent data extraction and quality assessment of studies were conducted according to the PRISMA statement. Finally, we identified 16 articles and found that some interventions (i.e., prebiotic, probiotic, vitamin A supplementation, antibiotics, and fecal microbiota transplantation) could alter the gut microbiota and improve behavioral symptoms and GI symptoms among ASD patients. Our findings highlight that the gut microbiota could be a novel target for ASD patients in the future. However, we only provided su...Continue Reading

Citations

Jun 24, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jason A BubierGeorge M Weinstock
Jun 27, 2021·Autism Research : Official Journal of the International Society for Autism Research·Qiming TanAndrea M Haqq
Jul 3, 2021·Journal of Personalized Medicine·María Luján Ferreira, Nicolás Loyacono
Nov 5, 2021·Journal of Gastroenterology and Hepatology·Karen M J WallerSudarshan Paramsothy

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