PMID: 8590052Sep 11, 1995Paper

Effects of GYKI 52466 and CNQX, AMPA/kainate receptor antagonists, on the micturition reflex in the rat

Brain Research
M YoshiyamaW C de Groat

Abstract

GYKI 52466, a non-competitive AMPA/kainate glutamate receptor antagonist, administered in graded doses (0.5-8 mg/kg, i.v.) at 10 min intervals, decreased the amplitude and duration of reflex bladder contractions (maximal inhibition = 63%), the intercontraction interval (maximal inhibition = 83%) and external urethral sphincter activity (maximal inhibition = 91%) in urethane-anesthetized (1.2 g/kg, s.c.) intact rats during continuous transurethral cystometrograms. On the other hand, in unanesthetized decerebrate rats, the drug did not alter reflex bladder activity but did produce a significant depression of sphincter activity (maximal inhibition = 59%). The depressant effects of single doses of GYKI 52466 (4 mg/kg, i.v.) on external urethral sphincter EMG activity occurred with similar time courses in both urethane-anesthetized (1.2 g/kg, s.c.) intact and unanesthetized decerebrate rats during continuous transurethral cystometrograms. In urethane-treated (0.6 g/kg, i.p.) decerebrate rats, GYKI 52466 (0.5-4 mg/kg, i.v.) depressed bladder contraction amplitude and sphincter EMG activity, similar to the effects in urethane-anesthetized (1.2 g/kg, s.c.) intact rats. CNQX (0.01-1 mg/kg, i.v.), a competitive AMPA/kainate receptor anta...Continue Reading

Citations

Feb 24, 2001·Japanese Journal of Pharmacology·H KontaniS Kimura
Feb 22, 2008·American Journal of Physiology. Renal Physiology·Shwu-Fen PanTzer-Bin Lin
Mar 23, 2007·American Journal of Physiology. Renal Physiology·Jiuan-Miaw LiaoTzer-Bin Lin
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
Jul 2, 1998·The Journal of Urology·O YokoyamaM Namiki
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Jul 20, 2007·American Journal of Physiology. Renal Physiology·Gin-Den ChenTzer-Bin Lin
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karl B Thor, William C de Groat
Jul 12, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kimio SugayaYoshihide Ogawa
Jul 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mitsuharu YoshiyamaMasayuki Takeda
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Masaru YoshizumiMasahito Kawatani

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