Effects of H-7 (protein kinase inhibitor) and phorbol ester on aortic strips from spontaneously hypertensive rats

European Journal of Pharmacology
R ShibataT Iwasaki

Abstract

We investigated the vascular responsiveness to vasoactive agents and the inhibition by H-7 (1-(5-isoquinoline-sulfonyl)-2-methylpiperazine), which inhibits cyclic nucleotide-dependent protein kinases and protein kinase C(PKC) equally potently in helically cut strips of thoracic aortas from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The susceptibility of norepinephrine (NE)- and angiotensin II (Ang II)-induced contractions to H-7 was significantly higher in the aortas from SHR than in those from WKY. H-7 decreased the contractile responses to KCl to a similar extent in both strains without affecting the high K(+)-stimulated Ca2+ influx. H-7 produced a shift to the right of the dose-response curve for the PKC activator, 12-o-tetradecanoylphorbol-13-acetate (TPA) in the case of SHR aortas, while no such shift was noted in tissues from WKY. Functional alterations in the PKC branch of the Ca2+ messenger system in vascular smooth muscle may play an important role in SHR during the sustained contraction.

References

Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Jun 30, 1987·Biochemical and Biophysical Research Communications·M J MacKay, D W Cheung
Oct 1, 1987·Journal of Hypertension·A M Heagerty, J D Ollerenshaw
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·D F Bohr, R C Webb
Jan 1, 1989·Annual Review of Pharmacology and Toxicology·D M Chuang
Apr 29, 1987·European Journal of Pharmacology·E A Suba, B L Roth
Feb 1, 1987·The American Journal of Physiology·H Itoh, K Lederis
Dec 1, 1988·The American Journal of Physiology·C M Rembold, R A Murphy
Sep 1, 1986·The American Journal of Physiology·M Chatterjee, M Tejada
Aug 14, 1986·Biochemical and Biophysical Research Communications·M M Gleason, S F Flaim
Dec 15, 1986·Biochemical and Biophysical Research Communications·K TakaoriT Takeda
Dec 28, 1984·Biochemical and Biophysical Research Communications·N R Danthuluri, R C Deth
Jul 31, 1984·Biochemical and Biophysical Research Communications·H RasmussenA Scriabine

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Citations

Sep 24, 1991·European Journal of Pharmacology·M D LogranoC Galli
Aug 6, 1992·European Journal of Pharmacology·S T Abraham, P J Rice
Mar 3, 1992·European Journal of Pharmacology·P J SilverA L Harris
Aug 3, 1993·European Journal of Pharmacology·J DuarteJ Tamargo
Nov 2, 1992·European Journal of Pharmacology·E BazanR M Rapoport
Jul 1, 1995·European Journal of Pharmacology·I WakabayashiK Hatake
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·E O Okoro, J F Marwood
Jun 1, 1994·The American Journal of Physiology·J N LorenzN Sperelakis

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