Effects of hallucinogens on locomotor and investigatory activity and patterns: influence of 5-HT2A and 5-HT2C receptors

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Kirsten Krebs-ThomsonMark A Geyer

Abstract

The 5-HT2A and 5-HT2C antagonists MDL 100,907 and SER-082 were tested with the 5-HT2A/C agonist DOI and the 5-HT1A/2A/2C agonist LSD in the Behavioral Pattern Monitor, which provides multiple measures of locomotor and investigatory activity. Previous investigations have shown that these measures load onto three independent behavioral factors: amount of activity, exploratory behavior, and behavioral organization. Rats pretreated with saline, MDL 100,907 (0.25-2.0 mg/kg), or SER-082 (0.5-1.0 mg/kg) were treated with saline, 0.25 mg/kg DOI, or 60 micrograms/kg LSD. All effects of DOI were blocked by all doses of MDL 100,907, but only by the highest dose of SER-082. While the effects of LSD on activity and exploratory behavior were largely unaffected, either pretreatment antagonized the effects of LSD on behavioral organization. Thus, all of these effects of DOI were attributable to 5-HT2A receptors, whereas the effect of LSD on behavioral organization was influenced by both 5-HT2A and 5-HT2C receptors.

Citations

Nov 26, 2009·Psychopharmacology·Adam L Halberstadt, Mark A Geyer
Jan 5, 2007·Journal of Computer-aided Molecular Design·Zhuoyong ZhangYuhong Xiang
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·T KoskinenJ Sirviö
Mar 26, 2003·Brain Research. Molecular Brain Research·Charles D NicholsElaine Sanders-Bush
Nov 19, 2002·Neuroscience·C D NicholsE Sanders-Bush
Jan 22, 2013·ACS Chemical Neuroscience·James B Hanks, Javier González-Maeso
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam L HalberstadtSusan B Powell
Dec 17, 2010·Zebrafish·Caio Maximino, Anderson Manoel Herculano
Dec 15, 2010·Journal of Psychopharmacology·Adam L HalberstadtMark A Geyer
May 10, 2012·Behavioural Brain Research·Shoji TanakaMark A Geyer
Jun 22, 2010·Behavioural Brain Research·Leah GrossmanAllan V Kalueff
Feb 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomás PálenícekJirí Horácek
Apr 9, 2015·Frontiers in Pharmacology·Bruno P Guiard, Giuseppe Di Giovanni
Dec 21, 2010·Pharmacology, Biochemistry, and Behavior·Tomáš PáleníčekCyril Höschl
Jan 25, 2011·Neuropharmacology·Adam L Halberstadt, Mark A Geyer
Jul 19, 2014·Behavioural Brain Research·Adam L Halberstadt
Jun 12, 2013·The International Journal of Neuropsychopharmacology·José L Moreno, Javier González-Maeso
Jun 5, 2019·Acta Crystallographica. Section E, Crystallographic Communications·Balakrishnan RajeswariKasthuri Balasubramani
Sep 22, 2017·Acta Crystallographica. Section E, Crystallographic Communications·Md Serajul Haque FaiziTetyana Yu Sliva
Jan 31, 2021·Pharmacology, Biochemistry, and Behavior·M L Shawn Bates, Keith A Trujillo
Oct 3, 2017·Neuropharmacology·Jun GaoMing Li
May 15, 2008·Chemical Reviews·David E Nichols, Charles D Nichols
Apr 18, 2018·ACS Chemical Neuroscience·Lindsay P CameronDavid E Olson
Sep 1, 2011·Progress in Neurobiology·Philippe HuotJonathan M Brotchie

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