Effects of halothane and calcium entry blockers on atrioventricular conduction-a comparative study of verapamil, diltiazem, and nifedipine

Journal of Anesthesia
S YokotaO Kemmotsu

Abstract

The effects of halothane on AV nodal function were evaluated in dogs with verapamil, diltiazem, or nifedipine during atrial pacing using the technique of His-bundle electrocardiography. Fifty-one mongrel dogs were divided into six groups. Anesthesia was induced with ketamine 100 mg im. and thiamylal 25 mg/kg iv. The animals were intubated and mechanically ventilated at normocapneic levels. Anesthesia was maintained with 50% nitrous-oxide in oxygen with pancuronium 2 mg im. Dogs in groups I, III, and V were anesthetized with 0.8% halothane and 50% nitrous-oxide in oxygen. We observed interactions between halothane and intravenous administration of either verapamil 0.1 mg/kg, diltiazem 0.15 mg/kg, or nifedipine 0.01 mg/kg respectively. Dogs in groups II, IV, and VI were administered either verapamil, diltiazem, or nifedipine iv without halothane. There were prolongations of sinus cycle length (SCL) (414 +/- 10 to 542 +/- 19 msec.), atrium-His (AH) interval (73 +/- 3 to 97 +/- 5 msec.), and functional refractory period (FRP) of the AV-node (227 +/- 5 to 260 +/- 5 msec.) in halothane anesthesia in groups I, III, and V. There were more prolongations of these variables after iv administration of verapamil (SCL; 617 +/- 35, AH; 118 +/...Continue Reading

References

Nov 1, 1978·Anesthesiology·M G Pratila, V Pratilas
May 1, 1977·Anesthesia and Analgesia·J L Atlee, S C Alexander
Oct 1, 1985·Anesthesia and Analgesia·N IwatsukiK Amaha
Nov 1, 1970·British Journal of Anaesthesia·G Brichard, P E Zimmermann
Sep 1, 1982·Progress in Cardiovascular Diseases·J V Talano, C Tommaso
Feb 18, 1982·The American Journal of Cardiology·L B MitchellJ W Mason
Feb 18, 1982·The American Journal of Cardiology·J J RozanskiA Castellanos
Oct 1, 1981·Anesthesiology·C LynchN Sperelakis

❮ Previous
Next ❯

Citations

Oct 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K SatoO Kemmotsu

❮ Previous
Next ❯