Effects of halothane, isoflurane and sevoflurane on ischemia-reperfusion injury in the perfused liver of fasted rats

Acta Anaesthesiologica Scandinavica
M ImaiH Inaba

Abstract

Although intraoperative ischemia-reperfusion of the liver generally occurs under general anesthesia, little is known about the direct effect of anesthetic agents on hepatic injury due to this phenomenon. The effect of volatile anesthetics on ischemia-reperfusion injury was studied using isolated liver perfusion. The liver was isolated from 24-h-fasted male Sprague-Dawley rats and perfused through the portal vein with a modified Krebs-Ringer bicarbonate solution in a recirculating perfusion-aeration system. Ischemia was induced by reducing the baseline perfusion pressure from 1.2 to 0.2 kPa followed by reperfusion to baseline level. The ischemia-reperfusion injury was assessed by LDH release from the perfused liver. We studied the effect of halothane, isoflurane and sevoflurane on the ischemia-reperfusion injury during 20 min of control conditions, exposure of the liver to 60 min of ischemia and reperfusion for 90 min. Ischemia was evident by reduced portal vein flow and oxygen consumption, and caused an increase in lactate production. Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release. All anesthetics reduced hepatic oxygen consumption and increased the net lactate productio...Continue Reading

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Citations

Jun 13, 2002·Acta Anaesthesiologica Scandinavica·H ReineltM Schmidt
Jan 25, 2003·International Anesthesiology Clinics·S A Leonard, H P Redmond
Jul 11, 2006·Current Opinion in Anaesthesiology·Phillip F PrattDavid C Warltier
May 28, 2005·Anesthesia and Analgesia·Stefan G De HertDavid F Stowe
Aug 12, 2014·European Journal of Anaesthesiology·Siluê Z F Dal MolinMario R Alvares-da-Silva
Aug 5, 2015·Journal of Neuroinflammation·Samaneh MaysamiCatherine B Lawrence
Jul 19, 2005·Biochemical and Biophysical Research Communications·Gao-Hong ZhangYong-Tang Zheng
Mar 20, 2012·Journal of Pediatric Surgery·Cuneyt TaymanFatih Andiran
Jun 24, 2005·American Journal of Surgery·Elijah DixonFrancis Sutherland
May 24, 2008·The Annals of Thoracic Surgery·Howard K SongRoss M Ungerleider
Jul 14, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·M-L GuyeV Piriou
Aug 1, 2012·Biochemical and Biophysical Research Communications·Yan-Mei ZhangGang-Gang Shi
Mar 12, 2016·International Journal of Immunopathology and Pharmacology·Ji LiHuan-Qiu Liu
Jun 16, 2001·Journal of Applied Physiology·B H HeijnenT M van Gulik
May 25, 2013·European Journal of Anaesthesiology·Shao-Peng ZhouHua Liu

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