Effects of halothane on the electroencephalogram of the chicken

Veterinary Medicine and Science
Amanda E McIlhoneDavid J Mellor

Abstract

Little is known about the effects of inhalant anaesthetics on the avian electroencephalogram (EEG). The effects of halothane on the avian EEG are of interest, as this agent has been widely used to study nociception and analgesia in mammals. The objective of this study was to characterize the effects of halothane anaesthesia on the EEG of the chicken. Twelve female Hyline Brown chickens aged 8-10 weeks were anaesthetized with halothane in oxygen. For each bird, anaesthesia was progressively increased from 1-1.5 to 2 times the Minimum Anesthetic Concentration (MAC), then progressively decreased again. At each concentration, a sample of EEG was recorded after a 10-min stabilization period. The mean Total Power (PTOT ), Median Frequency (F50) and 95% Spectral Edge Frequency (F95) were calculated at each halothane MAC, along with the Burst Suppression Ratio (BSR). Burst suppression was rare and BSR did not differ between halothane concentrations. Increasing halothane concentration from 1 to 2 MAC resulted in a decrease in F50 and increase in PTOT , while F95 increased when MAC was reduced from 1.5 to 1. The results indicate dose-dependent spectral EEG changes consistent with deepening anaesthesia in response to increasing halothane ...Continue Reading

References

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Mar 19, 2014·Veterinary Anaesthesia and Analgesia·Amanda E McIlhoneDavid J Mellor

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Citations

Mar 8, 2020·Animals : an Open Access Journal From MDPI·Charissa HarrisSabrina Lomax
Oct 10, 2018·Frontiers in Human Neuroscience·Antonia FleischmannMatthias Kreuzer

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