Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT

Maturitas
J LaraM Siervo

Abstract

Hypertension is a major contributor to the global burden of cardiovascular diseases and its prevalence increases progressively with ageing. Therefore the identification of effective, age-friendly exercise and nutritional interventions which lower blood pressure (BP) is a research priority. To undertake a pilot RCT examining the efficacy of isometric handgrip exercise (IHGE) and beetroot juice (a rich source of inorganic nitrate) consumption in modifying clinic and 24-h ambulatory BP (24-h ABP), peripheral arterial function and plasma asymmetric dimethylarginine (ADMA) in older overweight and obese adults. Thirty middle age and older adults (62±5 years) were randomised to: (a) bilateral IHGE at 50% of maximal voluntary contraction (8 min/day), (b) 140 ml/day of concentrated beetroot juice, or (c) no-intervention (control group), for 7 days. All groups followed a standardised diet to control nitrate intake. Clinic and 24-h ABP, peripheral arterial function quantified by pulse wave velocity (PWV) and arterial volume distensibility were assessed before and after intervention. Clinical ageing research unit, Newcastle University. At baseline, there were no between-group differences in age, handgrip strength, clinic or 24-h ABP, BMI, ...Continue Reading

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Citations

May 18, 2017·Nutrition Research Reviews·Ann Ashworth, Raul Bescos
Sep 10, 2017·Journal of the American Heart Association·Konstantin SchwarzMichael P Frenneaux
Apr 11, 2018·The American Journal of Clinical Nutrition·Lauren C BlekkenhorstCatherine P Bondonno
Jan 11, 2020·Nutrition & Metabolism·Parvin MirmiranFereidoun Azizi
Jan 4, 2021·Aging Clinical and Experimental Research·Antonio Capurso, Cristiano Capurso
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Thiago Silveira AlvaresJuan Manuel Murias
Aug 15, 2017·Molecular Aspects of Medicine·Catherine P BondonnoJonathan M Hodgson
Oct 7, 2021·Nutrition Reviews·Laís de Souza Gouveia MoreiraDenise Mafra

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