Effects of heat shock on protein processing and turnover in developing Drosophila wings

Developmental Genetics
N S Petersen, P Young

Abstract

Developmental defects called phenocopies can be induced by heating Drosophila melanogaster pupae at specific developmental stages. The induction of the defects is thought to be a result of interference with gene expression at some level (Petersen and Mitchell, Dev Biol 1987; 121:335-341, 1987). Here we look at protein turnover in developing 52-hour wings and at the effect of heat on the proteolytic processing of three proteins that normally turn over rapidly. The effect of the heat treatment itself on the turnover of each protein is different. However, all of the proteins appear to be stabilized at 25 degrees C during recovery from severe heat shocks.

References

Jan 1, 1986·Annual Review of Biochemistry·S Lindquist
May 1, 1985·Molecular and Cellular Biology·U Bond, M J Schlesinger
Jun 1, 1987·Developmental Biology·N S Petersen, H K Mitchell
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H K MitchellC H Buzin
Feb 1, 1983·Developmental Biology·H K MitchellN S Petersen
Feb 1, 1983·Developmental Biology·H K Mitchell, N S Petersen
Jan 1, 1984·Annual Review of Genetics·F C NeidhardtV Vaughn
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N S Petersen, H K Mitchell
Jul 15, 1981·Developmental Biology·H K Mitchell, N S Petersen

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Citations

Nov 2, 1999·Development, Growth & Differentiation·K L Chow, K W Chan
Nov 6, 1998·FEBS Letters·G Hassanzadeh GhC Dambly-Chaudière
Jan 15, 1994·American Journal of Medical Genetics·B L RodgersM A Sens
Jul 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Lewis I Held
Sep 3, 2002·Mechanisms of Development·Lewis I Held
Sep 15, 1995·Genes & Development·M A WelteS Lindquist

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