Effects of Helicobacter pylori eradication among adults with intellectual disability

Journal of Intellectual Disability Research : JIDR
R A WallaceP M Webb

Abstract

Compared to the general population, Helicobacter pylori infection is more common among adults with intellectual disability (ID) and is associated with greater levels of disability, maladaptive behaviour, and institutionalization. Little information exists about the effects of eradication therapy in this group, so we aimed to evaluate: (1) success of a standard H. pylori eradication protocol; (2) frequency of side-effects; and (3) impact of eradication on level of functional ability and maladaptive behaviour. A cohort of adults with ID underwent assessment of their levels of function and maladaptive behaviour, medical history, physical examination, and H. pylori testing using serology and faecal antigen tests. Some received standard H. pylori eradication therapy. Twelve months later, participants underwent repeat assessment, were grouped by change in H. pylori status and compared. Of 168 participants, 117 (70%) were currently infected with H. pylori at baseline, and 96 (82%) of the 117 were given standard H. pylori eradication therapy. The overall eradication rate was 61% but 31% reported side-effects. Institutional status of the participants, their level of behaviour or function, and number of comorbid medical conditions were n...Continue Reading

References

Mar 1, 1996·Helicobacter·R W van der HulstG N Tytgat
Jan 16, 1998·Journal of Intellectual Disability Research : JIDR·S Reiss, M G Aman
May 30, 1998·British Medical Bulletin·A Harris

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Citations

Oct 9, 2003·Journal of Clinical Microbiology·Robyn A WallacePenelope M Webb
Sep 12, 2006·Journal of Intellectual Disability Research : JIDR·G Galli-CarminatiN Deriaz
Nov 2, 2007·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Dinah H KitchensDouglas Darling
Feb 14, 2012·Disability and Rehabilitation. Assistive Technology·Kup-Sze ChoiWai-Yee Chung
Mar 20, 2004·Internal Medicine Journal·R A WallaceP M Webb
Jan 11, 2017·Journal of Psychiatric Practice·Nicholas H NeufeldKenneth Shulman

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