Abstract
To explore the consequences of helium/oxygen (He/O(2)) inhalation on respiratory mechanics, gas exchange, and ventilation-perfusion (VA/Q) relationships in an animal model of severe induced bronchospasm during mechanical ventilation. Prospective, interventional study. Experimental animal laboratory, university hospital. Seven piglets were anesthetized, paralyzed, and mechanically ventilated, with all ventilator settings remaining constant throughout the protocol. Acute stable bronchospasm was obtained through continuous aerosolization of methacholine. Once steady-state was achieved, the animals successively breathed air/O(2) and He/O(2) (FIO(2) 0.3), or inversely, in random order. Measurements were taken at baseline, during bronchospasm, and after 30 min of He/O(2) inhalation. Bronchospasm increased lung peak inspiratory pressure (49+/-6.9 vs 18+/-1 cm H(2)O, P<0.001), lung resistance (22.7+/-1.5 vs 6.8+/-1.5 cm H(2)O x l(-1).s, P<0.001), dynamic elastance (76+/-11.2 vs 22.8+/-4.1 cm H(2)O x l(-1), P<0.001), and work of breathing (1.51+/-0.26 vs 0.47+/-0.08, P<0.001). Arterial pH decreased (7.47+/-0.06 vs 7.32+/-0.06, P<0.001), PaCO(2) increased, and PaO(2) decreased. Multiple inert gas elimination showed an absence of shunt, s...Continue Reading
References
Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W Evans, P D Wagner
Sep 1, 1992·The American Review of Respiratory Disease·T J WilliamsG Bowes
Sep 1, 1991·Journal of Applied Physiology·A M Lauzon, J H Bates
Jul 1, 1991·The American Review of Respiratory Disease·R Rodriguez-RoisinJ Roca
Sep 1, 1990·Chest·E H GluckR Castriotta
Jul 1, 1990·The American Journal of Medicine·J K ManselJ R Norman
Mar 1, 1989·The American Review of Respiratory Disease·R Rodriguez-RoisinP D Wagner
Mar 1, 1988·Chest·C S SassoonR W Light
Jul 1, 1987·Journal of Applied Physiology·P H BreenL D Wood
Oct 1, 1987·The American Review of Respiratory Disease·D V Tuxen, S Lane
Apr 1, 1985·The American Review of Respiratory Disease·G A RossiR G Crystal
May 1, 1974·Journal of Applied Physiology·P D WagnerJ B West
Sep 1, 1983·The American Review of Respiratory Disease·J G MartinL A Engel
Jun 1, 1995·Intensive Care Medicine·A RossiG Conti
Jan 1, 1995·Respiration Physiology·D Papamoschou
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·C A ManthousL D Wood
Mar 1, 1995·Chest·J E Kass, R J Castriotta
Jun 1, 1994·Journal of Applied Physiology·B K EricksonP D Wagner
Sep 1, 1995·The Journal of Burn Care & Rehabilitation·D A RodebergG D Warden
Nov 1, 1995·Experimental Lung Research·H SchulzJ Heyder
Feb 1, 1997·The Journal of Pediatrics·T M KudukisM E Wylam
Jun 1, 1997·The European Respiratory Journal·R Rodriguez-Roisin
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D TassauxJ C Chevrolet
Dec 1, 1999·Critical Care Medicine·P JollietJ C Chevrolet
Jan 11, 2000·Critical Care Medicine·E M SchaefferJ B Hall
Aug 31, 2000·Critical Care Medicine·D TassauxJ C Chevrolet
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·A J OrsiniV M Nadkarni
Jun 13, 2001·The European Respiratory Journal·A L EchazarretaR Rodriguez-Roisin
Nov 20, 2001·Chest·B AfessaJ D Cury
Jan 26, 2002·Intensive Care Medicine·F AdnetF Lapostolle
Jan 16, 2003·Intensive Care Medicine·Christine WatremezGiuseppe Liistro
Dec 1, 1949·Journal of Applied Physiology·A B OTIS, W C BEMBOWER
Citations
Jun 1, 2010·Animal : an International Journal of Animal Bioscience·J C Litten-BrownL Clarke
Aug 31, 2006·Acta Anaesthesiologica Scandinavica·H NormanL Larsson
Jan 13, 2005·Critical Care Medicine·Rachana K Visaria, Dwayne R Westenskow
Sep 22, 2007·Critical Care Medicine·Lars Larsson
Aug 5, 2004·Intensive Care Medicine·Edward AbrahamBenoit Vallet
May 28, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer A BartlettKatherine E Williams