Effects of hemicholinium-3 and choline on hippocampal electrical activity during immobility vs. movement

Electroencephalography and Clinical Neurophysiology
T E Robinson, D J Green

Abstract

Earlier studies have shown that the hippocampal rhythmical slow activity (RSA or theta) which may occur during behavioral immobility (IRSA) is abolished by systemically administered atropine (is atropine-sensitive), although the RSA which accompanies movements, such as walking, running or swimming (MRSA) is atropine-resistant. This study was designed to manipulate brain cholinergic activity in ways other than through the use of postsynaptic receptor antagonists, and to determine the effects of such manipulations on IRSA and MRSA. The IRSA elicited by electrical stimulation of the reticular formation in urethanized rats was severely attenuated by intraventricular injections of hemicholinium-3 (HC-3), a drug which depletes brain acetylcholine. A subsequent systemic injection of choline chloride restored IRSA elicited by electrical stimulation. In contrast, HC-3 had no deleterious effects on the MRSA recorded from freely moving rats. Therefore, atropine-sensitive IRSA is also HC-3 sensitive, and atropine-resistant MRSA is also HC-3 resistant. These results support the hypothesis that there are two pharmacologically distinct neurochemical systems which may produce hippocampal RSA. It is suggested that acetylcholine is necessary for...Continue Reading

References

Apr 1, 1977·Brain Research·T E RobinsonC H Vanderwolf
Mar 1, 1978·Brain Research Bulletin·R K Cooley, C H Vanderwolf
Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·R W Russell, J Macri
Apr 15, 1977·Brain Research·M J HirschR J Wurtman
Sep 8, 1977·The New England Journal of Medicine·J H GrowdonW Wiener
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Apr 7, 1971·Journal of Chromatography·W J Wolf, B W Thomas
Nov 24, 1956·Nature·R I BIRKSP B SASTRY
Nov 1, 1961·The Biochemical Journal·J E GARDINER
Dec 1, 1962·Electroencephalography and Clinical Neurophysiology·P B BRADLEY, A N NICHOLSON

❮ Previous
Next ❯

Citations

Sep 1, 1987·Neuroscience and Behavioral Physiology·E S Brazhnik, O S Vinogradova
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·D J StewartC H Vanderwolf
Jan 1, 1986·Progress in Neurobiology·B H Bland
Jun 1, 1983·Neuroscience·M GlavinovićB Collier
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vinay ParikhMartin Sarter
Jan 3, 2013·The European Journal of Neuroscience·Tomasz KowalczykJan Konopacki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.