Effects of hemodialysis and long-term erythropoietin treatment on protein C, and on free and total protein S

Thrombosis Research
N ClyneL E Lins

Abstract

We studied 37 hemodialysis patients during hemodialysis in order to assess the effects of dialysis on endogenous plasma coagulation inhibitors (antithrombin III, protein C, free and total protein S). The patients were examined prior to erythropoietin (EPO) treatment, upon reaching target hemoglobin (Hb) and after 3 months at steady state Hb levels. The levels of protein C increased significantly during dialysis. However, EPO treatment did not affect the levels of any of the endogenous coagulation inhibitors, either upon reaching target Hb or after 3 months of steady state Hb. The sequence of change during dialysis of protein C, free and total protein S was constant when comparing respective patterns prior to EPO treatment to those at target Hb and steady state Hb respectively. In conclusion, hemodialysis seems to activate synthesis of endogenous coagulation while partial correction of anaemia with EPO does not affect the levels of these inhibitors.

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Citations

Nov 25, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kenan BekKemal Baysal
Oct 28, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pak-Hei ChanChung-Wah Siu
Oct 4, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ján StaskoPeter Kubisz
Dec 5, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ján Stasko, Peter Kubisz
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A G ChristenssonS R Lethagen
Jun 1, 2003·Hemodialysis International·Sydney C W Tang, Kar Neng Lai
Mar 30, 2011·The International Journal of Artificial Organs·James A MilburnJulie Brittenden

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