Abstract
We studied 37 hemodialysis patients during hemodialysis in order to assess the effects of dialysis on endogenous plasma coagulation inhibitors (antithrombin III, protein C, free and total protein S). The patients were examined prior to erythropoietin (EPO) treatment, upon reaching target hemoglobin (Hb) and after 3 months at steady state Hb levels. The levels of protein C increased significantly during dialysis. However, EPO treatment did not affect the levels of any of the endogenous coagulation inhibitors, either upon reaching target Hb or after 3 months of steady state Hb. The sequence of change during dialysis of protein C, free and total protein S was constant when comparing respective patterns prior to EPO treatment to those at target Hb and steady state Hb respectively. In conclusion, hemodialysis seems to activate synthesis of endogenous coagulation while partial correction of anaemia with EPO does not affect the levels of these inhibitors.
References
Jan 1, 1978·Nephron·G RemuzziG de Gaetano
Sep 1, 1992·Kidney International·A CasesR Castillo
Jan 1, 1992·Nephron·N ArikS Caglar
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I C MacdougallJ D Williams
Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F FabrisA Girolami
Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G ViganòG Remuzzi
Jan 1, 1990·Nephron·K N LaiP K Li
Oct 15, 1989·Thrombosis Research·J Petäjä
Jan 1, 1989·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E Sundal, U Kaeser
Jan 1, 1989·Blood Purification·F KnudsenJ Dyerberg
Nov 28, 1987·Lancet·M MoiaC Ponticelli
Sep 1, 1988·The American Journal of the Medical Sciences·W J StoneT P Pincus
Jan 1, 1987·Nephron·A AlegreI Alberca
Jan 1, 1985·British Journal of Haematology·F FernandezB Boneu
Nov 6, 1982·Lancet·M LivioG de Gaetano
Mar 1, 1994·Journal of the American Society of Nephrology : JASN·P Zaoui, R M Hakim
Sep 1, 1994·The Journal of Clinical Investigation·B Dahlbäck
Jul 1, 1993·Kidney International·J E TaylorW K Stewart
Citations
Nov 25, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kenan BekKemal Baysal
Aug 11, 1998·Urology·J A Brown, A Nehra
Oct 28, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pak-Hei ChanChung-Wah Siu
Oct 4, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ján StaskoPeter Kubisz
Dec 5, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ján Stasko, Peter Kubisz
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A G ChristenssonS R Lethagen
Jun 1, 2003·Hemodialysis International·Sydney C W Tang, Kar Neng Lai
Mar 30, 2011·The International Journal of Artificial Organs·James A MilburnJulie Brittenden
Aug 3, 2017·Journal of Arrhythmia·Chern-En ChiangWee Siong Teo