Effects of hemodialysis on circulating adrenomedullin concentrations in patients with end-stage renal disease

Blood Purification
M ToepferH Schiffl


To characterize the determinants of circulating levels of adrenomedullin (AM), the plasma levels of this peptide were measured in 58 patients with end-stage renal disease on hemodialysis. Predialysis plasma levels of AM were more than twice as high in patients on hemodialysis as compared to controls. In hemodialysis patients with heart failure (NYHA classes II-IV) or hypertensive HD patients plasma levels of AM were significantly higher than in patients with end-stage renal disease only. Plasma levels of AM were not altered immediately by hemodialysis but decreased significantly 14-20 h after hemodialysis. AM plasma levels before hemodialysis and 14-20 h after hemodialysis were correlated with the corresponding mean arterial pressure.


Dec 19, 2003·Advances in Renal Replacement Therapy·William R Clark, James F Winchester
Mar 23, 2006·Seminars in Dialysis·James F Winchester, Patrick F Audia
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Koichi KanozawaToshiro Fujita

Related Concepts

Arterial Pulse Pressure
ADM gene
Chronic Kidney Disease Stage 5
Kidney Failure, Chronic
Hypertensive Disease

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