PMID: 11903148Mar 21, 2002Paper

Effects of hemoglobin-based blood substitutes on vasoactivity of rat aortic rings

Artificial Organs
L F de FigueiredoG C Kramer

Abstract

Our objective is to characterize the vasoactive properties of a 10% alphaalpha diaspirin cross-linked human hemoglobin (alphaalphaHb) and to test the hypothesis that sodium nitroprusside (SNP)-induced relaxation is inhibited in the presence of alphaalphaHb. Experiments were performed on aortic rings from 18 Wistar rats; the rings were suspended in aerated Krebs solution. Changes in isometric tension were measured to increasing concentrations of alphaalphaHb (1.8 x 10(-9) to 10(-4) M) on phenylephrine (PE)-induced contraction (3 x 10(-7) M), on acetylcholine (ACh)-induced relaxation (10(-8) to 10(-6) M), on SNP-induced relaxation (10(-9) and 10(-8) M), and on PE-induced contraction with an endothelin-1 (ET1) receptor antagonist, BQ123 (10(-5) M). Control rings received no alphaalphaHb. A concentration-dependent increase of the PE-precontraction (1.3%, 6.8%, 17.4%, and 34%, respectively) as well as the inhibition and reversal of ACh-induced relaxation was observed after alphaalphaHb. The presence of alphaalphaHb decreased the SNP-induced relaxation in the presence or absence of endothelium. The relaxation induced by SNP was reduced with time in the presence, but not in the absence, of alphaalphaHb. In conclusion, although pharmac...Continue Reading

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Citations

Dec 24, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·N TsunookaK Kawachi
Apr 9, 2014·Journal of Chemical Biology·Bruno R SilvaLusiane M Bendhack
Jan 1, 1997·Critical Care : the Official Journal of the Critical Care Forum·L F FigueiredoG C Kramer
Nov 7, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Joao B G CerqueiraNilberto R F Nascimento

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