PMID: 8946339Nov 6, 1996Paper

Effects of hepatic nerve stimulation on blood glucose and glycogenolysis in rat liver: studies with in vivo microdialysis

Journal of the Autonomic Nervous System
A TakahashiY Maruyama

Abstract

In vivo microdialysis was applied to investigate the effects of hepatic nerve stimulation on glycogenolysis in rat liver under anesthesia. We analyzed the norepinephrine (NE) outflow and glucose output from the liver through the measurement of NE and glucose in the microdialysis dialyzate, as well as the plasma glucose level. Stimulation of the hepatic nerves (10 Hz, 20 V, 2 ms, 20 s every minute) increased NE outflow and glucose output from the liver. The blood glucose level increased by 1.5-1.6 times over the basal level at the end of the 10 min intermittent stimulation. Bilateral adrenalectomy and pancreatectomy did not abolish the glycogenolysis that was induced by the nerve stimulation. Phentolamine an alpha-antagonist, reduced the effects of nerve stimulation on the glucose output and the plasma glucose level. Phentolamine caused an increase in the NE outflow. Quinacline, an inhibitor of phospholipase A2, inhibited the glycogenolytic nerve effects without any inhibition of the NE outflow. These data show that hepatic nerve stimulation produces glycogenolysis via alpha-adrenergic mechanism and partly mediated by eicosanoids, and that microdialysis is a useful and simple method for the study of liver metabolism in physiolog...Continue Reading

References

Sep 11, 1990·European Journal of Biochemistry·K Decker
Jun 1, 1989·Journal of Neurochemistry·H Benveniste
Jan 1, 1988·Advances in Enzyme Regulation·J KuiperT J Van Berkel
Jan 1, 1987·Diabetes/metabolism Reviews·T Shimazu
Jan 1, 1987·Advances in Enzyme Regulation·K JungermannH Hartmann
Jan 1, 1983·Progress in Neurobiology·W W Lautt
Sep 1, 1981·Journal of the Autonomic Nervous System·A Takahashi, T Shimazu
Jan 1, 1980·Anatomy and Embryology·W Metz, W G Forssmann

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Citations

Dec 21, 2002·Autonomic Neuroscience : Basic & Clinical·Ayumi SugimotoMieko Kurosawa
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Wolfgang Langhans
Feb 5, 2010·Journal of Lipid Research·Jen-Chieh ChuangMichael Lutter
Jul 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J ChenJ D Z Chen
Oct 28, 2004·Autonomic Neuroscience : Basic & Clinical·Rie Shimoju-KobayashiMieko Kurosawa
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Gerhard P Püschel
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoki UyamaHendrik Reynaert
Aug 6, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·O KoukouiL Combettes

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