Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

Acta Cirúrgica Brasileira
K G B AbegãoR M B Nogueira

Abstract

To evaluate the potential of heterologous platelet-rich plasma (PRP) gel for surgical skin wound healing in rabbits. Blood from a single healthy dog was used for PRP production, with calcium gluconate added to the PRP to form the gel. Two surgical excisions, one to the right and the other to the left of the dorsal midline, were made in six rabbits. One side was randomly allocated to topical application of a physiological solution, and the other was allocated to treatment with heterologous PRP gel. Clinical assessments (weight, pain sensitivity, coloring, edema, hyperemia, exudation, crust, and granulation) and morphometric evaluations were performed 0, 3, 7, 10, 14, and 17 days postoperatively. Histological analysis was performed on the 17th day. With the exception of the presence of a crust at day 10, clinical variables did not differ significantly between the experimental groups. In both the control and PRP-treated groups, differences were identified when comparing time-points in terms of wound area reduction. Histological results indicated no significant differences between the control group and the PRP-treated group. Heterologous platelet-rich plasma gel promoted dermal wound healing in rabbits with no adverse effects.

References

Jun 25, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·R E MarxK R Georgeff
Aug 12, 2009·Anais Brasileiros De Dermatologia·Ricardo José de Mendonça, Joaquim Coutinho-Netto
Aug 26, 2009·Acta Cirúrgica Brasileira·Rafael DeRossiKarine Bonucielli Brum
Nov 3, 2012·Acta Cirúrgica Brasileira·Larissa Correa HermetoAureo Evangelista Santana
Feb 16, 2013·Journal of Biomaterials Applications·Shuko SuzukiYoshito Ikada
Mar 20, 2013·The International Journal of Lower Extremity Wounds·Gui-Qiu ShanZheng-Liang Chen

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Citations

Jan 19, 2018·Journal of Functional Biomaterials·Deborah Chicharro-AlcántaraJoaquín J Sopena-Juncosa
Aug 20, 2020·Acta Cirúrgica Brasileira·Bruno Watanabe MintoAndresa Matsui
Nov 26, 2020·Acta Cirúrgica Brasileira·Raquel de Oliveira MeiraLuiz Ronaldo Alberti
Feb 19, 2021·Journal of Medical Case Reports·Vincenzo Davide PalumboAttilio Ignazio Lo Monte
Mar 23, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shujun WangBaoan Chen

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