Effects of hexachlorocyclohexane (HCH) on the contractile response induced by norepinephrine in the rat isolated vas deferens.

Pharmacology & Toxicology
D N Gandhi, H Venkatakrishna-Bhatt

Abstract

Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium. Preparations incubated in excess Ca++ (4.2 mM) or in Ca++-free Krebs solution showed decrease in sensitivity to NE. The inhibitory action of HCH reduced the sensitivity and decreased maximum responses to NE in any Mg++ concentration of the medium. In the normal Ca++ and its deficient medium decrease in sensitivity to HCH and the relevant maximum response to NE were observed. In excess Ca++, the HCH effect depressed corresponding to its maximal response to NE. The presence of EDTA depressed the HCH effect irrespective of the Ca++ influence on the receptors.

References

Dec 1, 1976·Toxicology and Applied Pharmacology·J P HanigS Krop
Oct 1, 1969·Archives internationales de physiologie et de biochimie·C Van Breemen
Jan 1, 1969·The American Journal of Physiology·I TasakiA Watanabe
Apr 1, 1971·The American Journal of Physiology·B M Altura, B T Altura
Apr 4, 1974·Pflügers Archiv : European journal of physiology·R Deth, C van Breemen
Jan 1, 1983·General Pharmacology·M AldegundeM P Fernandez Otero
May 1, 1983·Biological Reviews of the Cambridge Philosophical Society·P Gerolt

❮ Previous
Next ❯

Citations

Jul 1, 1991·Agents and Actions·D N Gandhi, H Venkatakrishna-Bhatt
Dec 29, 1999·Reproductive Toxicology·K A Criswell, R Loch-Caruso
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rita Loch-CarusoJames E Trosko
Oct 22, 2003·Reproductive Biology and Endocrinology : RB&E·Rita K Loch-CarusoKelly A Brant
Mar 23, 2005·Fukushima Journal of Medical Science·Hironori NakanishiNorimichi Nakahata
Oct 18, 2008·Fukushima Journal of Medical Science·Hironori NakanishiNorimichi Nakahata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
K SrinivasanR Radhakrishnamurty
Journal of Toxicology and Environmental Health
M K Srivastava, R B Raizada
© 2022 Meta ULC. All rights reserved