PMID: 9550285Jan 1, 1997Paper

Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats

L L KosudaP E Bigazzi


Repeated exposure of Brown Norway (BN) rats to relatively low doses of HgCl2 induces autoantibodies to renal antigens (e.g., laminin) and a membranous glomerulonephropathy characterized by proteinuria. In contrast, Lewis (LEW) rats are "resistant" to the autoimmune effects of mercury and, when exposed to this metal, are protected against experimental autoimmune encephalomyelitis (EAE) and Heymann's nephritis. To date, there is no information on "suppressive" effects of mercury in naturally occurring (so-called "spontaneous") rat models of autoimmune disease. Therefore, we have administered HgCl2 to diabetes-prone (DP) BB rats, animals that spontaneously develop both insulin-dependent diabetes mellitus (IDDM) and thyroiditis. We found that DP rats treated with mercury or water for a period of 40-125 days developed autoantibodies to thyroglobulin, with a higher incidence in HgCl2-injected animals (92% vs. 56% in H2O-injected controls). A novel finding of our study was the detection of autoantibodies to laminin in the same rats, again with an increased incidence after HgCl2 treatment (83% vs. 44%). IgG2a was the most frequently detected isotype of antibodies to laminin, followed by IgG1, IgG2b and IgG2c. The IgG isotype profile su...Continue Reading


Nov 1, 1992·Clinical Immunology and Immunopathology·P E Bigazzi
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D Bellgrau, A C Lagarde
Jan 1, 1990·Scandinavian Journal of Immunology·L PelletierP Druet
Jan 1, 1987·European Journal of Immunology·L PelletierP Druet
Nov 1, 1988·Clinical Immunology and Immunopathology·G A HenryP E Bigazzi
Jan 1, 1988·Methods in Enzymology·P E Bigazzi
Aug 1, 1987·Kidney International·L PelletierP Druet
Oct 1, 1987·Clinical Immunology and Immunopathology·A FukatsuG A Andres
Apr 1, 1982·Diabetes·M ElderT McConnell
Sep 1, 1982·Diabetes·A A LikeA A Rossini
Apr 15, 1983·Archives of Biochemistry and Biophysics·E EngvallE Ruoslahti
Jan 1, 1980·Journal of Immunoassay·D de Savigny, A Voller
Jan 1, 1994·Methods in Enzymology·U M Wewer, E Engvall
Jan 1, 1995·Clinical Immunology and Immunopathology·A A RossiniD L Greiner
Jun 1, 1993·Environmental Health Perspectives·L L KosudaP E Bigazzi
Jun 1, 1996·European Journal of Immunology·J A Gracie, J A Bradley

❮ Previous
Next ❯


Nov 5, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P E BigazziD L Greiner
Sep 30, 1999·Environmental Health Perspectives·P E Bigazzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.