Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Shanzana I KhanJaye P F Chin-Dusting

Abstract

Despite its well-known antithrombotic properties, the effect of aspirin on blood pressure (BP) and hypertension pathology is unclear. The hugely varying doses used clinically have contributed to this confusion, with high-dose aspirin still commonly used due to concerns about the efficacy of low-dose aspirin. Because prostaglandins have been shown to both promote and inhibit T-cell activation, we also explored the immunomodulatory properties of aspirin in hypertension. Although the common preclinical high dose of 100 mg/kg/d improved vascular dysfunction and cardiac hypertrophy, this effect was accompanied by indices of elevated adaptive immunity, renal T-cell infiltration, renal fibrosis, and BP elevation in stroke-prone spontaneously hypertensive rats and in angiotensin II-induced hypertensive mice. The cardioprotective effects of aspirin were conserved with a lower dose (10 mg/kg/d) while circumventing heightened adaptive immunity and elevated BP. We also show that low-dose aspirin improves renal fibrosis. Differential inhibition of the COX-2 isoform may underlie the disparate effects of the 2 doses. Our results demonstrate the efficacy of low-dose aspirin in treating a vast array of cardiovascular parameters and suggest modu...Continue Reading

References

Oct 1, 1990·Regulatory Toxicology and Pharmacology : RTP·E M VoisinP C Hoyle
Aug 25, 1986·The American Journal of Medicine·L ScharschmidtM J Dunn
Sep 1, 1988·Biopharmaceutics & Drug Disposition·R ObachJ Vallès
Nov 8, 1993·Archives of Internal Medicine·J F FriesJ P Raynauld
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·A R AminS B Abramson
Aug 8, 2002·Kidney International·Masaomi NangakuRichard J Johnson
May 17, 2005·Current Pharmaceutical Design·H F Cheng, R C Harris
Sep 15, 2005·British Journal of Pharmacology·Pascale GluaisMichel Feletou
Jul 28, 2006·British Journal of Clinical Pharmacology·Henry J McQuay, R Andrew Moore
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Jun 3, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael D HughsonJohn F Bertram
Jan 22, 2009·British Journal of Pharmacology·Michel FélétouPaul M Vanhoutte
Feb 2, 2010·Trends in Pharmacological Sciences·G Enrico RovatiGiancarlo Folco
Jun 5, 2010·Current Hypertension Reports·Leonelo E Bautista, Lina M Vera
Dec 15, 2010·Hypertension·David G HarrisonCornelia M Weyand
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Bernardo Rodríguez-IturbeRichard J Johnson
Jan 22, 2011·Journal of Translational Medicine·José M López-NovoaFrancisco J López Hernández
Jan 26, 2011·Hypertension·Tlili BarhoumiErnesto L Schiffrin
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Sep 29, 2011·Immunology and Cell Biology·Vinatha SreeramkumarNatalia Cuesta
Dec 21, 2011·Circulation·Joseph A Vita
Jun 25, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicholas S KirkbyJane A Mitchell
Jun 1, 2008·Electrolyte & Blood Pressure : E & BP·Gheun-Ho Kim
Mar 15, 2015·Circulation Research·William G McMasterDavid G Harrison
Oct 21, 2015·The Journal of Clinical Investigation·Ming-Zhi ZhangRaymond C Harris
Nov 10, 2015·Biochemical Society Transactions·Melania DovizioPaola Patrignani
Jun 29, 2016·Clinical & Translational Immunology·Michael J KraakmanAndrew J Murphy
Jul 21, 2010·Pharmaceuticals·Walter H Hörl

❮ Previous
Next ❯

Citations

Sep 5, 2019·International Journal of Molecular Sciences·Shanzana KhanJaye P F Chin-Dusting

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Shanzana I KhanJaye P F Chin-Dusting
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Ana Catarina CostaTeresa Sousa
© 2022 Meta ULC. All rights reserved