PMID: 15222723Jun 30, 2004Paper

Effects of high altitude exposure on the pharmacokinetics of furosemide in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics
A ArancibiaW A Ritschel

Abstract

A cascade of pathophysiological events occurs with the ascension to high altitude (H). We have performed studies on the effects of exposure to H on the pharmacokinetics of drugs. The hypothesis behind these studies has been that the exposure to H, which produces marked physiological changes in the body, may alter pharmacokinetics, and consequently, pharmacodynamics. Our previous studies suggest that drugs highly bound to plasma proteins are most likely to exhibit altered disposition. In continuation of our research, we selected furosemide which is about 98% bound to plasma proteins, renally excreted and has low binding to red blood cells. Furosemide (40 mg) was administered orally to 3 groups of young healthy volunteers. One group who had been residing at sea level (group L), the same group after 15 hours of exposure to high altitude (3,600 m, group HA) and a group of volunteers living at H for at least 6 months (group HC). Our results are in accordance with the most recent pharmacokinetic studies on furosemide in which a terminal half-life of approximately 20-30 h was reported. Total proteins were 9.3% and 12.7% higher in groups HA and HC, respectively, than in group L. Albumin in group HC was 8.2% higher than group L. Bilirub...Continue Reading

Citations

Dec 21, 2007·New South Wales Public Health Bulletin·Paul Cozens
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Brian C FosterColin J Briggs
Jan 25, 2011·Journal of Clinical Pharmacology·Henry Tao Peng, Bob Cheung
Mar 22, 2015·Current Pain and Headache Reports·Michael J Marmura, Pablo Bandres Hernandez
Nov 15, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rüdiger GröningRotraut S Müller
Sep 8, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G DeschênesA Doucet
Mar 11, 2018·BMC Infectious Diseases·Lin Chen, Zhancheng Gao

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