PMID: 2122711Nov 1, 1990Paper

Effects of high carnitine supplementation on substrate utilization in low-birth-weight infants receiving total parenteral nutrition

The American Journal of Clinical Nutrition
E J SulkersP J Sauer

Abstract

Parenterally fed preterm neonates are known to be at risk for carnitine deficiency. We studied substrate utilization in low-birth-weight infants receiving total parenteral nutrition (TPN) with (A) and without (B) supplementation of 48 mg carnitine.kg-1.d-1 on days 4-7 (birth weights 1334 +/- 282 vs 1318 +/- 248 g, gestational age 32 +/- 2 vs 32 +/- 2 wk, A vs B, respectively). TPN consisted of 11 g glucose.kg-1.d-1 and 2.4 g.kg-1.d-1 of both protein and fat. Plasma carnitine concentrations at day 7 were for free carnitine 11.8 +/- 5.0 vs 164 +/- 56 mumol/L and for acyl carnitine 3.8 +/- 2.0 vs 33.9 +/- 15.4 mumol/L, respectively. Indirect calorimetry at day 7 showed a higher fat oxidation (0.21, -0.31 to +0.60 vs 1.18, 0.70 to 1.95 g. kg-1.d-1, respectively, P less than 0.02, median and interquartile range) in group B and a higher protein oxidation (0.37, 0.30-0.43 vs 0.63, 0.53-0.88 g.kg-1.d-1, P less than 0.001). The time to regain birth weight was also higher in group B (7, 5.5-9 vs 9, 7-14 d, P less than 0.05). Carnitine supplementation and calorie intake were the best explanatory variables for metabolic rate (R2 = 0.45, P less than 0.002). We conclude that carnitine supplementation of TPN in this dosage does not seem advis...Continue Reading

Citations

Oct 18, 2000·The Cochrane Database of Systematic Reviews·P A Cairns, D J Stalker
Apr 29, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Sumati PandeNora V Esteban-Cruciani
Jan 1, 1992·Nutrition Research Reviews·J B Morgan, I Z Kovar
Oct 21, 2004·The Cochrane Database of Systematic Reviews·M KumarB Paes
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine M Crill, Richard A Helms
Jun 1, 1996·Archives of Disease in Childhood·J H Walter
Jul 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·John A Kerner, Robert L Poole
Mar 18, 2000·The Medical Journal of Australia·G EggerR Stanton
Apr 2, 1999·Early Human Development·C CampoyJ A Molina-Font
Jun 24, 2004·Nutrition·Heidrun Karlic, Alfred Lohninger
Apr 3, 2002·Pediatrics·Jane O'DonnellKeith J Barrington

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