Effects of High-Dose, Short-Duration β-Alanine Supplementation on Cognitive Function, Mood, and Circulating Brain-Derived Neurotropic Factor (BDNF) in Recreationally-Active Males Before Simulated Military Operational Stress.

Journal of Dietary Supplements
Alyssa N VaranoskeJay R Hoffman

Abstract

Introduction: β-alanine (BA) supplementation may improve cognition and mitigate symptoms of anxiety and depression associated with aging, neurological disorders, and physical exertion, which has been attributed to increases in brain carnosine and/or brain-derived neurotropic factor (BDNF). BA also provides beneficial effects on cognition, mood, and physical performance during military operations; however, whether BA can attenuate mood disruptions and cognitive dysfunction associated with the anticipatory stress prior to simulated military operations is unknown.Purpose: The present study examined the effects of 14 days of BA (12 g·day-1) supplementation on cognitive function, mood, and circulating BDNF concentrations in recreationally-active, healthy males with limited inflammation and oxidative stress prior to a 24h simulated military operation.Methods: Participants were randomized into BA (n = 10) or placebo (n = 9; PL) for 14 days. Cognitive function, mood, and circulating BDNF were assessed before (PRE) and after (POST) supplementation. Cognition was assessed via multiple object tracking (Neurotracker™), visuomotor reaction time (Dynavision™), mathematical processing (Serial Subtraction Test), and neuropsychological assessme...Continue Reading

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R KohenB N Ames
Aug 1, 1974·Journal of Applied Physiology·D B Dill, D L Costill
Mar 23, 2001·The Clinical Neuropsychologist·J BleibergE Halpern
Dec 31, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alexander BoldyrevHiroki Abe
Sep 27, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·E MarianiP Mecocci
Mar 31, 2007·Behavior Research Methods·David R Thorne
Apr 2, 2008·Pharmacology, Biochemistry, and Behavior·Shozo TomonagaMitsuhiro Furuse
Aug 30, 2008·Rejuvenation Research·Alexander BoldyrevSerguey Illarioshkin
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirk I EricksonArthur F Kramer
Jul 8, 2010·The International Journal of Neuropsychopharmacology·Anders B KleinSusana Aznar
Apr 11, 2014·Journal of the International Society of Sports Nutrition·Jay R HoffmanIshay Ostfeld
May 31, 2014·Journal of Strength and Conditioning Research·Gerald T MangineJeffrey R Stout
Jun 2, 2014·Archives of Gerontology and Geriatrics·D SzcześniakJ Rymaszewska
Dec 5, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Laura BlancquaertWim Derave
Sep 15, 2015·Mechanisms of Ageing and Development·Soumyabrata BanerjeeMrinal K Poddar
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Tatsuhiro HisatsuneHiroshi Matsuda
Nov 1, 2016·British Journal of Sports Medicine·Bryan SaundersBruno Gualano
Sep 15, 2017·Journal of the American College of Nutrition·David D ChurchJeffrey R Stout
Nov 28, 2017·BMJ Open Sport & Exercise Medicine·Kjell N van ParidonMatt Bristow
Dec 12, 2017·Bioscience, Biotechnology, and Biochemistry·Shuntaro YamashitaYoshinori Katakura
Jul 13, 2018·Journal of the International Society of Sports Nutrition·Taylor FurstPeter J Horvath
Apr 19, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jay R HoffmanHagit Cohen

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Citations

Jan 12, 2021·Nutritional Neuroscience·Elske GravesteijnJogchum Plat
Apr 7, 2021·Psychonomic Bulletin & Review·Christian VaterAlex O Holcombe

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