Abstract
Paraquat (1,1'-dimethyl-4,4'-bipyridinium) (PQ), is a nonselective contact herbicide that is highly toxic to humans. The kidney is affected during PQ intoxication. Dexamethasone (Dexa) has anti-inflammatory effects and is used to treat cases of PQ poisoning. We investigated in rat kidney hemodynamic effects and immunohistochemical characteristics of Dexa treatment in acute PQ poisoning. Adult male rats were divided into four groups: 1, untreated control; 2, treated with 100 mg/kg Dexa; 3, treated with 25 mg/kg PQ; 4, treated with PQ + Dexa. Mean arterial pressure (MAP) and heart rate (HR) were recorded during the experimental period (2 h). Tissues were removed after 2 h and immunohistochemistry was performed after 24 h. Paraffin sections of kidney were prepared and anti-cyclo-oxygenase-1 (COX-1), anti-cyclo-oxygenase-2 (COX-2), anti-angiotensin converting enzyme (ACE), anti-aquaporin-1 (AQU-1), anti-vascular cell adhesion molecule (VCAM) primary antibodies were used for immunohistochemical examination. Immunoreactivities were scored as: (1) minimal, (2) weak, (3) mild, (4) moderate, (5) strong and (6) very strong. MAP and HR were measured at 10 min, 20 min, 1 h and 2 h. MAP at 10 and 20 min and 1 h was increased in the Dexa gro...Continue Reading
References
Aug 25, 1992·Biochemistry·M L ZeidelP Agre
Jul 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C BismuthC Keyes
Oct 19, 1993·Biochemical Pharmacology·R P Wuthrich, P Sekar
Sep 15, 1999·Molecular and Cellular Biochemistry·S Rajashree, R Puvanakrishnan
Jul 6, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·M Goppelt-StruebeH J Schaefers
Sep 22, 2001·Hypertension·C G LeonC P Vio
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Vicki L CliftonRoger Smith
Jul 13, 2002·Annals of the New York Academy of Sciences·Gunther Neeck
Mar 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Daniel J BrotmanSethu Reddy
Oct 4, 2005·FEBS Letters·Won Chung LimYoung Joo Lee
Jan 21, 2006·Critical Care Medicine·Ja-Liang LinWen-Hung Huang
May 12, 2006·American Journal of Physiology. Cell Physiology·Jian Ping MengBernard Bouscarel
Sep 8, 2006·Toxicology·R J Dinis-OliveiraFélix Carvalho
Jan 16, 2007·Digestive Diseases and Sciences·Aya YokotaKoji Takeuchi
Jun 15, 2007·Cellular and Molecular Life Sciences : CMLS·Y ImaiJ M Penninger
Jul 21, 2007·Free Radical Biology & Medicine·Mohamed SamaiPrabal K Chatterjee
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho
Apr 25, 2008·Journal of the American Society of Nephrology : JASN·Julie E GoodwinDavid S Geller
Jun 1, 1949·Annals of the Rheumatic Diseases·P S HenchH F Polley
Aug 1, 2008·Journal of the American Society of Nephrology : JASN·Chunling LiRobert W Schrier
Nov 26, 2008·Toxicology·R J Dinis-OliveiraF Carvalho
Sep 8, 2009·Journal of Neurosurgery·Nam D TranHarold F Young
Oct 20, 2009·Journal of the Chinese Medical Association : JCMA·Huan-Wen ChenLiang-Wen Ding
Feb 23, 2010·PloS One·Emilio A HerreraDino A Giussani