Effects of high-energy shock waves combined with biological response modifiers or Adriamycin on a human kidney cancer xenograft

Urological Research
G O OosterhofF M Debruyne

Abstract

We have studied the effect of high-energy shock waves (HESW) alone or in combination with biological response modifiers (BRMs) or Adriamycin on the growth of the NU-1 human kidney cancer xenograft. When HESW are administered repeatedly (four sessions of 800 shock waves on days 0, 2, 4 and 6) a prolonged delay in tumor growth was found compared with that following a single administration. This effect was temporary, and several days after stopping the HESW administration the tumor regained its original growth potential (same doubling time). Tumor growth was suppressed for a longer period by the combination of 4 sessions of HESW and a single administration of Adriamycin, 5 mg/kg. Combination of HESW treatment with interferon alpha (5.0 ng/g body weight, three times/week) and tumor necrosis factor alpha (500 ng/g body weight, 5 days/week) s.c. around the tumor resulted in a complete cessation of tumor growth. While Adriamycin had an additive effect on HESW treatment, the combination with BRMs was highly synergistic.

References

Jan 1, 1988·Urological Research·R F RandazzoJ B deKernion
Jul 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C BuzaidS E Salmon
Mar 1, 1986·The Journal of Urology·P RussoW R Fair

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Citations

Jan 1, 1994·Lasers in Surgery and Medicine·T M de ReijkeH J Sterenborg
Jan 1, 1996·Ultrasound in Medicine & Biology·G O OosterhofJ A Schalken
Jan 1, 1995·Ultrasound in Medicine & Biology·E B CornelG O Oosterhof
Jun 9, 2001·Ultrasound in Medicine & Biology·A E Worthington, M D Sherar
Jan 1, 1992·Ultrasound in Medicine & Biology·P SteinbachW Wieland
Jan 1, 1994·Ultrasound in Medicine & Biology·M SeidlF Hofstädter
Oct 26, 2000·Japanese Journal of Cancer Research : Gann·M KatoS Orikasa

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