Effects of high-fat diet on salivary α-amylase, serum parameters and food consumption in rats

Archives of Oral Biology
Lénia RodriguesElsa Lamy

Abstract

Salivary α-amylase, a major protein in saliva, has been described as a marker of sympathetic nervous system activity, hence for metabolic energy balance. In this context, its expression in overweight and obesity is of interest. Rats fed with a diet enriched with sunflower oil differentially gained weight yielding two subgroups according to their susceptibility (OP) or resistance (OR) to obesity. Elevated plasmatic levels of leptin in the OP subgroup and altered plasmatic lipid profiles (lower triglycerides and higher total cholesterol/high-density lipoprotein (HDL) ratio compared to controls) in the OR subgroup were observed. Animals from the OP subgroup presented higher α-amylase expression and activity even prior to the dietary treatment, suggesting that this salivary protein may constitute a putative indicator of susceptibility for fat tissue accumulation. After 18 weeks of high-fat diet consumption, salivary α-amylase levels did not significantly change in the OP subgroup, but increased 3-fold in the OR subgroup. The increase in α-amylase levels for the latter might represent an adaptation to lower starch intake. These results suggest that salivary α-amylase secretion might be useful to predict susceptibility for weight gai...Continue Reading

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Citations

Dec 1, 2015·Obesity Research & Clinical Practice·Martha Elisa Ferreira de AlmeidaRegiane Victória de Barros Fernandes
Aug 19, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Taye Jemilat LasisiAkinola Rasak Alada
Dec 21, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Lénia RodriguesElsa Lamy
Jul 29, 2017·Lipids in Health and Disease·Csaba CsonkaTamás Csont
Oct 27, 2017·Archives of Oral Biology·Jitjiroj IttichaicharoenSiriporn Chattipakorn
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla SimõesElsa Lamy

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