Effects of high NaCl diet on arterial pressure in Sprague-Dawley rats with hepatic and sinoaortic denervation

The Japanese Journal of Physiology
Shuang GaoHironobu Morita


The Na(+) receptor that exists in the hepatoportal region plays an important role in postprandial natriuresis and the regulation of Na(+) balance during NaCl load. Thus it would be considered that a dysfunction of the hepatic Na(+) receptor might result in the elevation of arterial pressure under a condition of high NaCl diet. To elucidate this hypothesis, arterial pressure was continuously measured during three weeks of high NaCl diet (8% NaCl) in four groups of rats: (i) intact rats, (ii) rats with hepatic denervation (HD), (iii) rats with sinoaortic denervation (SAD), and (iv) rats with SAD+HD. During a 1-week normal NaCl diet period, there was no difference in arterial pressure among the four groups. A high NaCl diet had no influence on arterial pressure in intact or HD rats; however, it significantly increased by 11 +/- 3 mmHg in SAD rats. The addition of HD to SAD had no synergistic effect on arterial pressure; i.e., in SAD+HD rats, mean arterial pressure increased by 13 +/- 1 mmHg. In conclusion, sinoaortic baroreceptor, but not hepatic Na(+) receptor, has a significant role in the long-term regulation of arterial pressure on a high NaCl diet.


Oct 1, 1985·Journal of Hypertension·P R HoweJ B Minson
Jul 14, 1995·Journal of the Autonomic Nervous System·H MoritaH Hosomi
Feb 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MatsudaM Okada
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·You TsuchiyaHironobu Morita

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Nov 7, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard D Wainford, Daniel R Kapusta
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